Detalles de la búsqueda
1.
2-(Halogenated Phenyl) acetamides and propanamides as potent TRPV1 antagonists.
Bioorg Med Chem Lett
; 48: 128266, 2021 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34273488
2.
Discovery of 1-(1H-indazol-4-yl)-3-((1-phenyl-1H-pyrazol-5-yl)methyl) ureas as potent and thermoneutral TRPV1 antagonists.
Bioorg Med Chem Lett
; 30(23): 127548, 2020 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32931910
3.
Discovery of indane propanamides as potent and selective TRPV1 antagonists.
Bioorg Med Chem Lett
; 30(3): 126838, 2020 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31864799
4.
Potent human glutaminyl cyclase inhibitors as potential anti-Alzheimer's agents: Structure-activity relationship study of Arg-mimetic region.
Bioorg Med Chem
; 26(5): 1035-1049, 2018 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29398442
5.
Structure-activity relationship investigation of Phe-Arg mimetic region of human glutaminyl cyclase inhibitors.
Bioorg Med Chem
; 26(12): 3133-3144, 2018 07 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-29705377
6.
6-Phenoxy-2-phenylbenzoxazoles, novel inhibitors of receptor for advanced glycation end products (RAGE).
Bioorg Med Chem
; 23(15): 4919-4935, 2015 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26051601
7.
Two ß-strands of RAGE participate in the recognition and transport of amyloid-ß peptide across the blood brain barrier.
Biochem Biophys Res Commun
; 439(2): 252-7, 2013 Sep 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-23973487
8.
Lipid-based colloidal nanoparticles for applications in targeted vaccine delivery.
Nanoscale Adv
; 5(7): 1853-1869, 2023 Mar 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-36998671
9.
Discovery of RC-752, a Novel Sigma-1 Receptor Antagonist with Antinociceptive Activity: A Promising Tool for Fighting Neuropathic Pain.
Pharmaceuticals (Basel)
; 16(7)2023 Jul 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37513874
10.
Discovery of potent indazole-based human glutaminyl cyclase (QC) inhibitors as Anti-Alzheimer's disease agents.
Eur J Med Chem
; 244: 114837, 2022 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36265279
11.
Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design.
Eur J Med Chem
; 226: 113819, 2021 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34536669
12.
Discovery of Benzopyridone-Based Transient Receptor Potential Vanilloid 1 Agonists and Antagonists and the Structural Elucidation of Their Activity Shift.
J Med Chem
; 64(1): 370-384, 2021 01 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-33385210
13.
O-GlcNAcylation ameliorates the pathological manifestations of Alzheimer's disease by inhibiting necroptosis.
Sci Adv
; 7(3)2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33523877
14.
Discovery of Nonpungent Transient Receptor Potential Vanilloid 1 (TRPV1) Agonist as Strong Topical Analgesic.
J Med Chem
; 63(1): 418-424, 2020 01 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31702924
15.
Discovery of dual-acting opioid ligand and TRPV1 antagonists as novel therapeutic agents for pain.
Eur J Med Chem
; 182: 111634, 2019 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31472474
16.
Discovery of Conformationally Restricted Human Glutaminyl Cyclase Inhibitors as Potent Anti-Alzheimer's Agents by Structure-Based Design.
J Med Chem
; 62(17): 8011-8027, 2019 09 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31411468
17.
Discovery of an Orally Bioavailable Benzofuran Analogue That Serves as a ß-Amyloid Aggregation Inhibitor for the Potential Treatment of Alzheimer's Disease.
J Med Chem
; 61(1): 396-402, 2018 01 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-29161514
18.
Effects of methamphetamine on single unit activity in rat medial prefrontal cortex in vivo.
Neural Plast
; 2007: 29821, 2007.
Artículo
en Inglés
| MEDLINE | ID: mdl-18288241
19.
Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer's Agents Based on Rational Design.
J Med Chem
; 60(6): 2573-2590, 2017 03 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-28234463
20.
Production of transgenic pig as an Alzheimer's disease model using a multi-cistronic vector system.
PLoS One
; 12(6): e0177933, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28586343