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1.
Development of a tetrahydroindazolone-based HDAC6 inhibitor with in-vivo anti-arthritic activity.
Bioorg Med Chem
; 99: 117587, 2024 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-38237257
2.
A novel HDAC6 inhibitor, CKD-504, is effective in treating preclinical models of huntington's disease.
BMB Rep
; 56(2): 178-183, 2023 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-36593104
3.
HDAC6 Inhibition Corrects Electrophysiological and Axonal Transport Deficits in a Human Stem Cell-Based Model of Charcot-Marie-Tooth Disease (Type 2D).
Adv Biol (Weinh)
; 6(2): e2101308, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34958183
4.
M-134, a novel HDAC6-selective inhibitor, markedly improved arthritic severity in a rodent model of rheumatoid arthritis when combined with tofacitinib.
Pharmacol Rep
; 73(1): 185-201, 2021 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-33188511
5.
CKD-506: A novel HDAC6-selective inhibitor that exerts therapeutic effects in a rodent model of multiple sclerosis.
Sci Rep
; 11(1): 14466, 2021 07 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-34262061
6.
Inhibition of histone deacetylase 6 suppresses inflammatory responses and invasiveness of fibroblast-like-synoviocytes in inflammatory arthritis.
Arthritis Res Ther
; 23(1): 177, 2021 07 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-34225810
7.
Therapeutic potential of CKD-506, a novel selective histone deacetylase 6 inhibitor, in a murine model of rheumatoid arthritis.
Arthritis Res Ther
; 22(1): 176, 2020 07 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-32711562
8.
Novel Histone Deacetylase 6 Inhibitor CKD-506 Inhibits NF-κB Signaling in Intestinal Epithelial Cells and Macrophages and Ameliorates Acute and Chronic Murine Colitis.
Inflamm Bowel Dis
; 26(6): 852-862, 2020 05 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31895948
9.
A novel histone deacetylase 6 inhibitor improves myelination of Schwann cells in a model of Charcot-Marie-Tooth disease type 1A.
Br J Pharmacol
; 177(22): 5096-5113, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-33460073
10.
CKD-506, a novel HDAC6-selective inhibitor, improves renal outcomes and survival in a mouse model of systemic lupus erythematosus.
Sci Rep
; 8(1): 17297, 2018 11 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-30470828
11.
Therapeutic effect of a novel histone deacetylase 6 inhibitor, CKD-L, on collagen-induced arthritis in vivo and regulatory T cells in rheumatoid arthritis in vitro.
Arthritis Res Ther
; 19(1): 154, 2017 07 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-28673326
12.
HDAC6 Inhibitors Rescued the Defective Axonal Mitochondrial Movement in Motor Neurons Derived from the Induced Pluripotent Stem Cells of Peripheral Neuropathy Patients with HSPB1 Mutation.
Stem Cells Int
; 2016: 9475981, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-28105056
13.
Effects of the anti-sepsis drug, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (CKD-712), on mortality, inflammation, and organ injuries in rodent sepsis models.
Arch Pharm Res
; 34(3): 485-94, 2011 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-21547682
14.
Neuroprotective effect of Buddleja officinalis extract on transient middle cerebral artery occlusion in rats.
Biol Pharm Bull
; 29(8): 1608-12, 2006 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-16880613
15.
Siberian ginseng reduces infarct volume in transient focal cerebral ischaemia in Sprague-Dawley rats.
Phytother Res
; 19(2): 167-9, 2005 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-15852490
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