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1.
Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids.
J Med Chem
; 34(3): 1155-61, 1991 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-2002456
2.
New quinolone antibacterial agents. Synthesis and biological activity of 7-(3,3- or 3,4-disubstituted-1-pyrrolidinyl)quinoline-3-carboxylic acids.
J Med Chem
; 33(2): 849-54, 1990 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-2153830
3.
A novel nonpeptide HIV-1 protease inhibitor: elucidation of the binding mode and its application in the design of related analogs.
J Med Chem
; 37(17): 2664-77, 1994 Aug 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-8064795
4.
Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids.
J Med Chem
; 31(5): 983-91, 1988 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-3361584
5.
Synthesis and antibacterial activity of new quinolones containing a 7-[3-(1-amino-1-methylethyl)-1-pyrrolidinyl] moiety. Gram-positive agents with excellent oral activity and low side-effect potential.
J Med Chem
; 37(6): 733-8, 1994 Mar 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-8145222
6.
Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy.
J Med Chem
; 36(7): 871-82, 1993 Apr 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-8385225
7.
New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk.
J Med Chem
; 35(2): 361-7, 1992 Jan 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-1732554
8.
Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship.
J Med Chem
; 34(3): 1142-54, 1991 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-1848296
9.
4-Hydroxy-5,6-dihydropyrones as inhibitors of HIV protease: the effect of heterocyclic substituents at C-6 on antiviral potency and pharmacokinetic parameters.
J Med Chem
; 44(14): 2319-32, 2001 Jul 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-11428926
10.
5,6-Dihydropyran-2-ones possessing various sulfonyl functionalities: potent nonpeptidic inhibitors of HIV protease.
J Med Chem
; 43(5): 843-58, 2000 Mar 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-10715152
11.
5-Amino-7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4- dihydro-4-oxo-3-quinolinecarboxylic acid (PD 124,816). Synthesis and biological evaluation of a new class of quinolone antibacterials.
Drugs Exp Clin Res
; 14(7): 453-60, 1988.
Artículo
en Inglés
| MEDLINE | ID: mdl-2853667
12.
7-substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials.
J Med Chem
; 31(3): 503-6, 1988 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-3346869
13.
Synthesis of 5,6-dihydro-4-hydroxy-2-pyrones as HIV-1 protease inhibitors: the profound effect of polarity on antiviral activity.
J Med Chem
; 40(23): 3707-11, 1997 Nov 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-9371233
14.
Discovery and optimization of nonpeptide HIV-1 protease inhibitors.
Bioorg Med Chem
; 4(9): 1401-10, 1996 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-8894098
15.
Nonpeptidic HIV protease inhibitors: 6-alkyl-5,6-dihydropyran-2-ones possessing achiral 3-(4-amino/carboxamide-2-t-butyl,5-methylphenyl thio) moiety: antiviral activities and pharmacokinetic properties.
Bioorg Med Chem Lett
; 9(11): 1481-6, 1999 Jun 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-10386921
16.
Nonpeptidic HIV protease inhibitors: 6-alkyl-5,6-dihydropyran-2-ones possessing a novel and achiral 3-(2-t-butyl-5-methyl-4-sulfamate)phenylthio moiety.
Bioorg Med Chem Lett
; 9(15): 2217-22, 1999 Aug 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-10465549
17.
Nonpeptidic HIV protease inhibitors possessing excellent antiviral activities and therapeutic indices. PD 178390: a lead HIV protease inhibitor.
Bioorg Med Chem
; 7(12): 2775-800, 1999 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-10658583
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