Detalles de la búsqueda
1.
A novel Menin-MLL1 inhibitor, DS-1594a, prevents the progression of acute leukemia with rearranged MLL1 or mutated NPM1.
Cancer Cell Int
; 23(1): 36, 2023 Feb 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-36841758
2.
Discovery of Novel 11-Membered Templates as Squalene Synthase Inhibitors.
J Med Chem
; 67(7): 5305-5314, 2024 Apr 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-38517948
3.
Discovery of novel tricyclic compounds as squalene synthase inhibitors.
Bioorg Med Chem
; 20(9): 3072-93, 2012 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22464687
4.
Discovery of atrop fixed alkoxy-aminobenzhydrol derivatives: novel, highly potent and orally efficacious squalene synthase inhibitors.
Bioorg Med Chem
; 19(17): 5207-24, 2011 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21802309
5.
Discovery of novel Thieno[2,3-d]pyrimidin-4-yl hydrazone-based cyclin-dependent kinase 4 inhibitors: synthesis, biological evaluation and structure-activity relationships.
Chem Pharm Bull (Tokyo)
; 59(8): 991-1002, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-21804244
6.
Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: a novel, potent and orally active direct inhibitor of factor Xa.
Bioorg Med Chem
; 17(3): 1193-206, 2009 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19128974
7.
Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: exploration of 5-6 fused rings as alternative S1 moieties.
Bioorg Med Chem
; 17(24): 8206-20, 2009 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19884015
8.
Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: exploration of 6-6 fused rings as alternative S1 moieties.
Bioorg Med Chem
; 17(24): 8221-33, 2009 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19900814
9.
DS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model.
Oncotarget
; 10(50): 5152-5167, 2019 Aug 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-31497246
10.
Synthesis and conformational analysis of a non-amidine factor Xa inhibitor that incorporates 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine as S4 binding element.
J Med Chem
; 47(21): 5167-82, 2004 Oct 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-15456260
11.
Discovery of DF-461, a Potent Squalene Synthase Inhibitor.
ACS Med Chem Lett
; 4(10): 932-6, 2013 Oct 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900587
12.
Cycloalkanediamine derivatives as novel blood coagulation factor Xa inhibitors.
Bioorg Med Chem Lett
; 17(16): 4683-8, 2007 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17555959
13.
Design, synthesis, and biological activity of novel factor Xa inhibitors: improving metabolic stability by S1 and S4 ligand modification.
Bioorg Med Chem
; 14(5): 1309-30, 2006 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16263291
14.
Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites.
Bioorg Med Chem
; 13(12): 3927-54, 2005 Jun 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-15911309
15.
Orally active factor Xa inhibitors: 4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine derivatives.
Bioorg Med Chem Lett
; 14(11): 2935-9, 2004 Jun 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-15125963
16.
Design, synthesis, and biological activity of non-amidine factor Xa inhibitors containing pyridine N-oxide and 2-carbamoylthiazole units.
Bioorg Med Chem
; 12(21): 5579-86, 2004 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15465335
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