Detalles de la búsqueda
1.
Exploring the Boundaries for In Vitro-In Vivo Extrapolation: Use of Isolated Rat Hepatocytes in Co-culture and Impact of Albumin Binding Properties in the Prediction of Clearance of Various Drug Types.
Drug Metab Dispos
; 51(11): 1463-1473, 2023 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-37580106
2.
Importance of the Unstirred Water Layer and Hepatocyte Membrane Integrity In Vitro for Quantification of Intrinsic Metabolic Clearance.
Drug Metab Dispos
; 46(3): 268-278, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29233818
3.
Characterization of the comparative drug binding to intra- (liver fatty acid binding protein) and extra- (human serum albumin) cellular proteins.
Xenobiotica
; 45(10): 847-57, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25801059
4.
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Arch Toxicol
; 87(8): 1315-530, 2013 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-23974980
5.
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
Drug Metab Dispos
; 40(1): 104-10, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-21998403
6.
Comparison of intrinsic clearances in human liver microsomes and suspended hepatocytes from the same donor livers: clearance-dependent relationship and implications for prediction of in vivo clearance.
Xenobiotica
; 41(2): 124-36, 2011 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-21058916
7.
Metabolite formation kinetics and intrinsic clearance of phenacetin, tolbutamide, alprazolam, and midazolam in adenoviral cytochrome P450-transfected HepG2 cells and comparison with hepatocytes and in vivo.
Drug Metab Dispos
; 38(9): 1449-55, 2010 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-20501911
8.
Prediction of human metabolic clearance from in vitro systems: retrospective analysis and prospective view.
Pharm Res
; 27(10): 2150-61, 2010 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-20661765
9.
Utilising Magnetically Isolated Lysosomes for Direct Quantification of Intralysosomal Drug Concentrations by LC-MS/MS Analysis: An Investigatory Study With Imipramine.
J Pharm Sci
; 109(9): 2891-2901, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32504630
10.
Prediction of in vivo drug-drug interactions from in vitro data : factors affecting prototypic drug-drug interactions involving CYP2C9, CYP2D6 and CYP3A4.
Clin Pharmacokinet
; 45(10): 1035-50, 2006.
Artículo
en Inglés
| MEDLINE | ID: mdl-16984215
11.
Evaluation of hepatic clearance prediction using in vitro data: emphasis on fraction unbound in plasma and drug ionisation using a database of 107 drugs.
J Pharm Sci
; 101(8): 2645-52, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22700322
12.
Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs.
Eur J Pharm Sci
; 45(5): 570-4, 2012 Apr 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-22214813
13.
Saturable uptake of lipophilic amine drugs into isolated hepatocytes: mechanisms and consequences for quantitative clearance prediction.
Drug Metab Dispos
; 35(8): 1325-32, 2007 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-17470525
14.
Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.
Drug Metab Rev
; 39(1): 159-234, 2007.
Artículo
en Inglés
| MEDLINE | ID: mdl-17364884
15.
Uptake and intracellular binding of lipophilic amine drugs by isolated rat hepatocytes and implications for prediction of in vivo metabolic clearance.
Drug Metab Dispos
; 34(11): 1829-36, 2006 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-16882765
16.
CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions.
J Pharmacol Exp Ther
; 314(1): 180-90, 2005 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-15784650
17.
Impact of parallel pathways of drug elimination and multiple cytochrome P450 involvement on drug-drug interactions: CYP2D6 paradigm.
Drug Metab Dispos
; 33(6): 837-44, 2005 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-15897600
18.
Prediction of metabolic clearance using cryopreserved human hepatocytes: kinetic characteristics for five benzodiazepines.
Drug Metab Dispos
; 33(12): 1852-8, 2005 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-16174807
19.
Quantitative prediction of the in vivo inhibition of diazepam metabolism by omeprazole using rat liver microsomes and hepatocytes.
Drug Metab Dispos
; 32(5): 572-80, 2004 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-15100181
20.
Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo.
Pharm Res
; 21(5): 819-26, 2004 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-15180340