Detalles de la búsqueda
1.
Development and evaluation of 2,4-disubstituted-5-aryl pyrimidine derivatives as antibacterial agents.
Arch Pharm (Weinheim)
; 357(4): e2300656, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-38304944
2.
Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Modification of the benzenoid part.
Bioorg Med Chem Lett
; 59: 128531, 2022 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35007723
3.
From EGFR kinase inhibitors to anti-inflammatory drugs: Optimization and biological evaluation of (4-(phenylamino)quinazolinyl)-phenylthiourea derivatives as novel NF-κB inhibitors.
Bioorg Chem
; 127: 105977, 2022 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35779404
4.
Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Optimization of the 2,4-substituents.
Bioorg Chem
; 117: 105422, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34700110
5.
Expanding the Myxochelin Natural Product Family by Nicotinic Acid Containing Congeners.
Molecules
; 26(16)2021 Aug 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-34443518
6.
Cystobactamid 507: Concise Synthesis, Mode of Action, and Optimization toward More Potent Antibiotics.
Chemistry
; 26(32): 7219-7225, 2020 Jun 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-31984562
7.
Hit optimization by dynamic combinatorial chemistry on Streptococcus pneumoniae energy-coupling factor transporter ECF-PanT.
Chem Commun (Camb)
; 60(7): 870-873, 2024 Jan 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-38164786
8.
Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle.
Adv Sci (Weinh)
; 10(5): e2204443, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36596691
9.
Sorbent extraction behavior of cesium and strontium from nitric acid solutions using a new high thermal stability material.
Appl Radiat Isot
; 180: 110058, 2022 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-34922309
10.
Structure-Guided Optimization of Small-Molecule Folate Uptake Inhibitors Targeting the Energy-Coupling Factor Transporters.
J Med Chem
; 65(13): 8869-8880, 2022 07 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-35709475
11.
NanoTafla Nanocomposite as a Novel Low-Cost and Eco-Friendly Sorbent for Strontium and Europium Ions.
ACS Omega
; 7(12): 10447-10457, 2022 Mar 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-35382267
12.
Targeting the IspD Enzyme in the MEP Pathway: Identification of a Novel Fragment Class.
ChemMedChem
; 17(5): e202100679, 2022 03 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-34918860
13.
Design and Synthesis of Novel Bis-Imidazolyl Phenyl Butadiyne Derivatives as HCV NS5A Inhibitors.
Pharmaceuticals (Basel)
; 15(5)2022 May 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-35631457
14.
Development of (4-Phenylamino)quinazoline Alkylthiourea Derivatives as Novel NF-κB Inhibitors.
Pharmaceuticals (Basel)
; 15(7)2022 Jun 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-35890077
15.
Redesigning of the cap conformation and symmetry of the diphenylethyne core to yield highly potent pan-genotypic NS5A inhibitors with high potency and high resistance barrier.
Eur J Med Chem
; 229: 114034, 2022 Feb 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-34959173
16.
Removal of strontium radionuclides from liquid scintillation waste and environmental water samples.
Appl Radiat Isot
; 166: 109357, 2020 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-32755756
17.
Synthesis and biological evaluation of 2-amino-7,7-dimethyl 4-substituted-5-oxo-1-(3,4,5-trimethoxy)-1,4,5,6,7,8-hexahydro-quinoline-3-carbonitrile derivatives as potential cytotoxic agents.
Bioorg Med Chem Lett
; 19(24): 6939-42, 2009 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19879135
18.
Development of potential preclinical candidates with promising in vitro ADME profile for the inhibition of type 1 and type 2 17ß-Hydroxysteroid dehydrogenases: Design, synthesis, and biological evaluation.
Eur J Med Chem
; 178: 93-107, 2019 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31176098
19.
Synthetic studies of cystobactamids as antibiotics and bacterial imaging carriers lead to compounds with high in vivo efficacy.
Chem Sci
; 11(5): 1316-1334, 2019 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34123255
20.
First Bispecific Inhibitors of the Epidermal Growth Factor Receptor Kinase and the NF-κB Activity As Novel Anticancer Agents.
J Med Chem
; 60(7): 2853-2868, 2017 04 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-28291344