Detalles de la búsqueda
1.
Preclinical exploration of combined glucagon inhibition and liver-preferential insulin for treatment of diabetes using in vitro assays and rat and mouse models.
Diabetologia
; 66(2): 376-389, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36404376
2.
Activation of insulin receptors and IGF-1 receptors in COLO-205 colon cancer xenografts by insulin and insulin analogue X10 does not enhance growth under normo- or hypoglycaemic conditions.
Diabetologia
; 61(11): 2447-2457, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30003309
3.
A framework for the in vitro evaluation of cancer-relevant molecular characteristics and mitogenic potency of insulin analogues.
Carcinogenesis
; 36(9): 1040-50, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-26026165
4.
Surface-expressed insulin receptors as well as IGF-I receptors both contribute to the mitogenic effects of human insulin and its analogues.
J Appl Toxicol
; 35(7): 842-50, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25413577
5.
In situ phosphorylation of Akt and ERK1/2 in rat mammary gland, colon, and liver following treatment with human insulin and IGF-1.
Toxicol Pathol
; 39(4): 623-40, 2011 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-21558470
6.
Unique expression pattern of the three insulin receptor family members in the rat mammary gland: dominance of IGF-1R and IRR over the IR, and cyclical IGF-1R expression.
J Appl Toxicol
; 31(4): 312-28, 2011 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-21259294
7.
Increased insulin receptor binding and increased IGF-1 receptor binding are linked with increased growth of L6hIR cell xenografts in vivo.
Sci Rep
; 10(1): 7247, 2020 04 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-32350367
8.
Intraintestinal and Parenteral Administration of an Insulin Analogue Leads to Comparable Activation of Signaling Downstream of the Insulin Receptor in the Small Intestine.
J Diabetes Sci Technol
; 14(1): 112-119, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31189343
9.
A-769662 activates AMPK beta1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle.
Am J Physiol Cell Physiol
; 297(4): C1041-52, 2009 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-19657063
10.
A novel high-affinity peptide antagonist to the insulin receptor.
Biochem Biophys Res Commun
; 376(2): 380-3, 2008 Nov 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-18782558
11.
A Novel Strategy to Prevent Advanced Atherosclerosis and Lower Blood Glucose in a Mouse Model of Metabolic Syndrome.
Diabetes
; 67(5): 946-959, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29483182
12.
Caffeine-induced impairment of insulin action but not insulin signaling in human skeletal muscle is reduced by exercise.
Diabetes
; 51(3): 583-90, 2002 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-11872654
13.
The alpha2-5'AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading.
Diabetes
; 53(12): 3074-81, 2004 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-15561936
14.
Synthesis and in vitro characterization of 1-(4-aminofurazan-3-yl)-5-dialkylaminomethyl-1H-[1,2,3]triazole-4-carboxylic acid derivatives. A new class of selective GSK-3 inhibitors.
J Med Chem
; 46(15): 3333-41, 2003 Jul 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-12852764
15.
Molecular characterisation of long-acting insulin analogues in comparison with human insulin, IGF-1 and insulin X10.
PLoS One
; 7(5): e34274, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22590494
16.
Systematic evaluation of the metabolic to mitogenic potency ratio for B10-substituted insulin analogues.
PLoS One
; 7(2): e29198, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22383948
17.
Dysregulation of glycogen synthase COOH- and NH2-terminal phosphorylation by insulin in obesity and type 2 diabetes mellitus.
J Clin Endocrinol Metab
; 94(11): 4547-56, 2009 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-19837931
18.
Phosphorylation-dependent translocation of glycogen synthase to a novel structure during glycogen resynthesis.
J Biol Chem
; 280(24): 23165-72, 2005 Jun 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-15840572
19.
AMP kinase activation ameliorates insulin resistance induced by free fatty acids in rat skeletal muscle.
Am J Physiol Endocrinol Metab
; 283(5): E965-70, 2002 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-12376323
20.
Use of transgenic models to understand effects of exercise on glucose metabolism.
Exerc Sport Sci Rev
; 30(2): 53-8, 2002 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-11991537