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1.
Derivation of oral cancer slope factors for hexavalent chromium informed by pharmacokinetic models and in vivo genotoxicity data.
Regul Toxicol Pharmacol
; 145: 105521, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37863416
2.
An adverse outcome pathway for small intestinal tumors in mice involving chronic cytotoxicity and regenerative hyperplasia: a case study with hexavalent chromium, captan, and folpet.
Crit Rev Toxicol
; 50(8): 685-706, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-33146058
3.
Exposure to environmentally-relevant concentrations of hexavalent chromium does not induce ovarian toxicity in mice.
Regul Toxicol Pharmacol
; 116: 104729, 2020 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-32652207
4.
Comparison of Gene Expression Responses in the Small Intestine of Mice Following Exposure to 3 Carcinogens Using the S1500+ Gene Set Informs a Potential Common Adverse Outcome Pathway.
Toxicol Pathol
; 47(7): 851-864, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31558096
5.
Integration of mechanistic and pharmacokinetic information to derive oral reference dose and margin-of-exposure values for hexavalent chromium.
J Appl Toxicol
; 38(3): 351-365, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29064106
6.
Assessment of the mutagenic potential of hexavalent chromium in the duodenum of big blue® rats.
Toxicol Appl Pharmacol
; 330: 48-52, 2017 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28687238
7.
Comparison of Toxicity and Recovery in the Duodenum of B6C3F1 Mice Following Treatment with Intestinal Carcinogens Captan, Folpet, and Hexavalent Chromium.
Toxicol Pathol
; 45(8): 1091-1101, 2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29161989
8.
Reduction of hexavalent chromium by fasted and fed human gastric fluid. II. Ex vivo gastric reduction modeling.
Toxicol Appl Pharmacol
; 306: 120-33, 2016 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27396814
9.
A chronic oral reference dose for hexavalent chromium-induced intestinal cancer.
J Appl Toxicol
; 34(5): 525-36, 2014 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-23943231
10.
Assessment of the mode of action underlying development of rodent small intestinal tumors following oral exposure to hexavalent chromium and relevance to humans.
Crit Rev Toxicol
; 43(3): 244-74, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-23445218
11.
Assessment of K-Ras mutant frequency and micronucleus incidence in the mouse duodenum following 90-days of exposure to Cr(VI) in drinking water.
Mutat Res
; 754(1-2): 15-21, 2013 Jun 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-23583686
12.
Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90days of exposure to hexavalent chromium in drinking water.
Toxicol Appl Pharmacol
; 259(1): 13-26, 2012 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22155349
13.
Assessment of genotoxic potential of Cr(VI) in the mouse duodenum: an in silico comparison with mutagenic and nonmutagenic carcinogens across tissues.
Regul Toxicol Pharmacol
; 64(1): 68-76, 2012 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-22705708
14.
Predictive modeling of biological responses in the rat liver using in vitro Tox21 bioactivity: Benefits from high-throughput toxicokinetics.
Comput Toxicol
; 182021 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-34013136
15.
Identifying Attributes That Influence In Vitro-to-In Vivo Concordance by Comparing In Vitro Tox21 Bioactivity Versus In Vivo DrugMatrix Transcriptomic Responses Across 130 Chemicals.
Toxicol Sci
; 167(1): 157-171, 2019 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30202884
16.
Letter to "Chepelev et al. Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose-response data: Margin of exposure case study of 48 compounds with both in vivo mutagenicity and carcinogenicity dose-response data".
Environ Mol Mutagen
; 64(4): 259-260, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36916184
17.
Estimating serum concentrations of dioxin-like compounds in the U.S. population effective 2005-2006 and 2007-2008: A multiple imputation and trending approach incorporating NHANES pooled sample data.
Environ Int
; 105: 112-125, 2017 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28527750
18.
Ten factors for considering the mode of action of Cr(VI)-induced gastrointestinal tumors in rodents.
Mutat Res Genet Toxicol Environ Mutagen
; 823: 45-57, 2017 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-28985946
19.
High-Throughput Screening Data Interpretation in the Context of In Vivo Transcriptomic Responses to Oral Cr(VI) Exposure.
Toxicol Sci
; 158(1): 199-212, 2017 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28472532
20.
A response to "A quantitative assessment of the carcinogenicity of hexavalent chromium by the oral route and its relevance to human exposure".
Environ Res
; 111(3): 468-70; discussion 471-2, 2011 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-21316655