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1.
Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140.
BMC Biol
; 20(1): 182, 2022 08 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-35986286
2.
Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate.
J Med Chem
; 65(3): 2262-2287, 2022 02 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34995458
3.
Identification of a Series of N-Methylpyridine-2-carboxamides as Potent and Selective Inhibitors of the Second Bromodomain (BD2) of the Bromo and Extra Terminal Domain (BET) Proteins.
J Med Chem
; 64(15): 10742-10771, 2021 08 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34232650
4.
Template-Hopping Approach Leads to Potent, Selective, and Highly Soluble Bromo and Extraterminal Domain (BET) Second Bromodomain (BD2) Inhibitors.
J Med Chem
; 64(6): 3249-3281, 2021 03 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-33662213
5.
Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors.
J Med Chem
; 64(15): 10772-10805, 2021 08 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34255512
6.
GSK973 Is an Inhibitor of the Second Bromodomains (BD2s) of the Bromodomain and Extra-Terminal (BET) Family.
ACS Med Chem Lett
; 11(8): 1581-1587, 2020 Aug 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-32832027
7.
The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor.
J Med Chem
; 63(17): 9093-9126, 2020 09 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32702236
8.
Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151).
J Med Chem
; 45(18): 3878-90, 2002 Aug 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-12190311
9.
A Flexible, Practical, and Stereoselective Synthesis of Enantiomerically Pure trans-5-Oxohexahydropyrrolo[3,2-b]pyrroles (Pyrrolidine-trans-lactams), a New Class of Serine Protease Inhibitors, Using Acyliminium Methodology.
J Org Chem
; 64(14): 5166-5175, 1999 Jul 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34237863
10.
Discovery of a brain-penetrant S1P3-sparing direct agonist of the S1P1 and S1P5 receptors efficacious at low oral dose.
J Med Chem
; 54(19): 6724-33, 2011 Oct 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-21838322
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