Detalles de la búsqueda
1.
Protein-protein interactions between the bilirubin-conjugating UDP-glucuronosyltransferase UGT1A1 and its shorter isoform 2 regulatory partner derived from alternative splicing.
Biochem J
; 450(1): 107-14, 2013 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23148825
2.
Refining the UGT1A haplotype associated with irinotecan-induced hematological toxicity in metastatic colorectal cancer patients treated with 5-fluorouracil/irinotecan-based regimens.
J Pharmacol Exp Ther
; 345(1): 95-101, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23386248
3.
KLRC1 knockout overcomes HLA-E-mediated inhibition and improves NK cell antitumor activity against solid tumors.
Front Immunol
; 14: 1231916, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37675109
4.
Shuttle Peptide Delivers Base Editor RNPs to Rhesus Monkey Airway Epithelial Cells In Vivo.
Res Sq
; 2023 Feb 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-36824928
5.
Isocitrate dehydrogenase 1 sustains a hybrid cytoplasmic-mitochondrial tricarboxylic acid cycle that can be targeted for therapeutic purposes in prostate cancer.
Mol Oncol
; 17(10): 2109-2125, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37086156
6.
Shuttle peptide delivers base editor RNPs to rhesus monkey airway epithelial cells in vivo.
Nat Commun
; 14(1): 8051, 2023 Dec 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-38052872
7.
Immunohistochemical expression of conjugating UGT1A-derived isoforms in normal and tumoral drug-metabolizing tissues in humans.
J Pathol
; 223(3): 425-35, 2011 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-21171088
8.
Multiple metabolic pathways fuel the truncated tricarboxylic acid cycle of the prostate to sustain constant citrate production and secretion.
Mol Metab
; 62: 101516, 2022 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35598879
9.
Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions.
J Biol Chem
; 285(6): 3600-3607, 2010 Feb 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-19996319
10.
Transcriptional diversity at the UGT2B7 locus is dictated by extensive pre-mRNA splicing mechanisms that give rise to multiple mRNA splice variants.
Pharmacogenet Genomics
; 21(10): 631-41, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21881541
11.
In vitro investigation of human UDP-glucuronosyltransferase isoforms responsible for tacrolimus glucuronidation: predominant contribution of UGT1A4.
Drug Metab Dispos
; 39(7): 1127-30, 2011 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-21487055
12.
Regulation of UGT1A1 and HNF1 transcription factor gene expression by DNA methylation in colon cancer cells.
BMC Mol Biol
; 11: 9, 2010 Jan 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-20096102
13.
Gene interactions in depression: pathways out of darkness.
Trends Genet
; 23(11): 547-56, 2007 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-17963976
14.
UGT genomic diversity: beyond gene duplication.
Drug Metab Rev
; 42(1): 24-44, 2010 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19857043
15.
Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro.
Drug Metab Dispos
; 38(10): 1785-9, 2010 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-20610558
16.
Copy-number variations (CNVs) of the human sex steroid metabolizing genes UGT2B17 and UGT2B28 and their associations with a UGT2B15 functional polymorphism.
Hum Mutat
; 30(9): 1310-9, 2009 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-19572376
17.
Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population.
Hum Mutat
; 30(4): 677-87, 2009 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-19204906
18.
Glucuronidation of the antiretroviral drug efavirenz by UGT2B7 and an in vitro investigation of drug-drug interaction with zidovudine.
Drug Metab Dispos
; 37(9): 1793-6, 2009 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-19487252
19.
Polymorphisms in the neuronal isoform of tryptophan hydroxylase 2 are associated with bipolar disorder in French Canadian pedigrees.
Psychiatr Genet
; 17(1): 17-22, 2007 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-17167340
20.
Phase II Drug-Metabolizing Polymorphisms and Smoking Predict Recurrence of Non-Muscle-Invasive Bladder Cancer: A Gene-Smoking Interaction.
Cancer Prev Res (Phila)
; 9(2): 189-95, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26645279