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1.
The conformational change of the protease inhibitor α2-macroglobulin is triggered by the retraction of the cleaved bait region from a central channel.
J Biol Chem
; 298(8): 102230, 2022 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35787371
2.
Structural Investigations of Human A2M Identify a Hollow Native Conformation That Underlies Its Distinctive Protease-Trapping Mechanism.
Mol Cell Proteomics
; 20: 100090, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-33964423
3.
Development of selective protease inhibitors via engineering of the bait region of human α2-macroglobulin.
J Biol Chem
; 297(1): 100879, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-34139236
4.
Mutation-induced dimerization of transforming growth factor-ß-induced protein may drive protein aggregation in granular corneal dystrophy.
J Biol Chem
; 297(1): 100858, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-34097874
5.
α2-Macroglobulin-like protein 1 can conjugate and inhibit proteases through their hydroxyl groups, because of an enhanced reactivity of its thiol ester.
J Biol Chem
; 295(49): 16732-16742, 2020 12 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32978260
6.
Substituting the Thiol Ester of Human A2M or C3 with a Disulfide Produces Native Proteins with Altered Proteolysis-Induced Conformational Changes.
Biochemistry
; 59(51): 4799-4809, 2020 12 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-33301305
7.
Recent cryogenic electron microscopy structures of human A2M may not be representative of the native protein.
Proc Natl Acad Sci U S A
; 119(37): e2210218119, 2022 09 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-35972981
8.
Bispecific light T-cell engagers for gene-based immunotherapy of epidermal growth factor receptor (EGFR)-positive malignancies.
Cancer Immunol Immunother
; 67(8): 1251-1260, 2018 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29869168
9.
Correction: α2-Macroglobulin-like protein 1 can conjugate and inhibit proteases through their hydroxyl groups, because of an enhanced reactivity of its thiol ester.
J Biol Chem
; 296: 100208, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-33837737
10.
Efficacy and toxicity management of CAR-T-cell immunotherapy: a matter of responsiveness control or tumour-specificity?
Biochem Soc Trans
; 44(2): 406-11, 2016 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27068947
11.
Proteolytic cleavage of the TGFß co-receptor CD109 changes its conformation, resulting in protease inhibition via activation of its thiol ester, and dissociation from the cell membrane.
FEBS J
; 2024 Apr 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-38587194
12.
Characterization of a Trispecific PD-L1 Blocking Antibody That Exhibits EGFR-Conditional 4-1BB Agonist Activity.
Antibodies (Basel)
; 13(2)2024 Apr 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-38804302
13.
Characterization of a novel cold-adapted intracellular serine protease from the extremophile Planococcus halocryophilus Or1.
Front Microbiol
; 14: 1121857, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-36910232
14.
A PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response.
Oncoimmunology
; 12(1): 2205336, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37114242
15.
Dendritic Cell-Mediated Cross-Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARS-CoV-2.
Adv Sci (Weinh)
; 10(34): e2304818, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37863812
16.
Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family.
Nat Commun
; 13(1): 3033, 2022 05 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-35641520
17.
Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer.
Oncoimmunology
; 11(1): 2034355, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35154908
18.
Tumor targeted 4-1BB agonist antibody-albumin fusions with high affinity to FcRn induce anti-tumor immunity without toxicity.
iScience
; 25(9): 104958, 2022 Sep 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-36072551
19.
Overcoming CAR-Mediated CD19 Downmodulation and Leukemia Relapse with T Lymphocytes Secreting Anti-CD19 T-cell Engagers.
Cancer Immunol Res
; 10(4): 498-511, 2022 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35362043
20.
An Fc-free EGFR-specific 4-1BB-agonistic Trimerbody Displays Broad Antitumor Activity in Humanized Murine Cancer Models without Toxicity.
Clin Cancer Res
; 27(11): 3167-3177, 2021 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33785484