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1.
Discovery of a stilbenoid-flavanone hybrid as an antitumor Wnt/ß-catenin signaling pathway inhibitor.
Bioorg Chem
; 145: 107178, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-38359708
2.
Repurposing of conformationally-restricted cyclopentane-based AKT-inhibitors leads to discovery of potential and more selective antileishmanial agents than miltefosine.
Bioorg Chem
; 141: 106890, 2023 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37783099
3.
Design, synthesis, and study of novel phenethyl-based antitumor phospholipids downregulating p38 mitogen-activated protein kinase.
J Enzyme Inhib Med Chem
; 38(1): 2217695, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37246947
4.
Rational repurposing, synthesis, in vitro and in silico studies of chromone-peptidyl hybrids as potential agents against Leishmania donovani.
J Enzyme Inhib Med Chem
; 38(1): 2229071, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37381756
5.
Nanomedicine as a putative approach for active targeting of hepatocellular carcinoma.
Semin Cancer Biol
; 69: 91-99, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-31421265
6.
Positional scanning of natural product hispidol's ring-B: discovery of highly selective human monoamine oxidase-B inhibitor analogues downregulating neuroinflammation for management of neurodegenerative diseases.
J Enzyme Inhib Med Chem
; 37(1): 768-780, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-35196956
7.
Discovery of novel and potent safinamide-based derivatives as highly selective hMAO-B inhibitors for treatment of Parkinson's disease (PD): Design, synthesis, in vitro, in vivo and in silico biological studies.
Bioorg Chem
; 115: 105233, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34390968
8.
Pyrrolidine-based 3-deoxysphingosylphosphorylcholine analogs as possible candidates against neglected tropical diseases (NTDs): identification of hit compounds towards development of potential treatment of Leishmania donovani.
J Enzyme Inhib Med Chem
; 36(1): 1922-1930, 2021 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-34425714
9.
Diarylurea derivatives comprising 2,4-diarylpyrimidines: Discovery of novel potential anticancer agents via combined failed-ligands repurposing and molecular hybridization approaches.
Bioorg Chem
; 103: 104121, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32745753
10.
Fluorinated CRA13 analogues: Synthesis, in vitro evaluation, radiosynthesis, in silico and in vivo PET study.
Bioorg Chem
; 99: 103834, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32334193
11.
Reprofiling of pyrimidine-based DAPK1/CSF1R dual inhibitors: identification of 2,5-diamino-4-pyrimidinol derivatives as novel potential anticancer lead compounds.
J Enzyme Inhib Med Chem
; 35(1): 311-324, 2020 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-31809612
12.
EGFR inhibitors from cancer to inflammation: Discovery of 4-fluoro-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide as a novel anti-inflammatory EGFR inhibitor.
Bioorg Chem
; 86: 112-118, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30685642
13.
Antiproliferative 3-deoxysphingomyelin analogs: Design, synthesis, biological evaluation and molecular docking of pyrrolidine-based 3-deoxysphingomyelin analogs as anticancer agents.
Bioorg Chem
; 84: 444-455, 2019 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30576908
14.
Design, synthesis and cytotoxicity of chimeric erlotinib-alkylphospholipid hybrids.
Bioorg Chem
; 84: 51-62, 2019 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30481646
15.
Optimization study towards more potent thiazolidine-2,4-dione IKK-ß modulator: Synthesis, biological evaluation and in silico docking simulation.
Bioorg Chem
; 92: 103261, 2019 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31542718
16.
Synthesis of oxidative metabolites of CRA13 and their analogs: Identification of CRA13 active metabolites and analogs thereof with selective CB2R affinity.
Bioorg Med Chem
; 26(18): 5069-5078, 2018 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30217464
17.
23-Hydroxyursolic Acid Isolated from the Stem Bark of Cussonia bancoensis Induces Apoptosis through Fas/Caspase-8-Dependent Pathway in HL-60 Human Promyelocytic Leukemia Cells.
Molecules
; 23(12)2018 Dec 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-30551620
18.
Hit discovery of 4-amino-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide: A novel EGFR inhibitor from a designed small library.
Bioorg Chem
; 75: 393-405, 2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29102722
19.
Synthesis and biological evaluation of picolinamides and thiazole-2-carboxamides as mGluR5 (metabotropic glutamate receptor 5) antagonists.
Bioorg Med Chem Lett
; 26(1): 140-4, 2016 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26598462
20.
Integrating computational methods guided the discovery of phytochemicals as potential Pin1 inhibitors for cancer: pharmacophore modeling, molecular docking, MM-GBSA calculations and molecular dynamics studies.
Front Chem
; 12: 1339891, 2024.
Artículo
en Inglés
| MEDLINE | ID: mdl-38318109