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1.
TYROBP/DAP12 knockout in Huntington's disease Q175 mice cell-autonomously decreases microglial expression of disease-associated genes and non-cell-autonomously mitigates astrogliosis and motor deterioration.
J Neuroinflammation
; 21(1): 66, 2024 Mar 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-38459557
2.
Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer's disease.
Alzheimers Dement
; 19(6): 2239-2252, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-36448627
3.
Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice.
Alzheimers Dement
; 17(2): 149-163, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33314529
4.
miR155 regulation of behavior, neuropathology, and cortical transcriptomics in Alzheimer's disease.
Acta Neuropathol
; 140(3): 295-315, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32666270
5.
Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau.
Mol Psychiatry
; 24(9): 1383-1397, 2019 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30283031
6.
Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aß amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aß burden.
Mol Psychiatry
; 24(3): 431-446, 2019 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30283032
7.
Correction: Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aß amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aß burden.
Mol Psychiatry
; 24(3): 472, 2019 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30464330
8.
Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology.
Acta Neuropathol
; 134(5): 769-788, 2017 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28612290
9.
BCI-838, an orally active mGluR2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the PS19 MAPTP301S mouse model of tauopathy.
Neurosci Lett
; 797: 137080, 2023 02 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-36657633
10.
Microglial TYROBP/DAP12 in Alzheimer's disease: Transduction of physiological and pathological signals across TREM2.
Mol Neurodegener
; 17(1): 55, 2022 08 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-36002854
11.
Transcriptomic Changes Highly Similar to Alzheimer's Disease Are Observed in a Subpopulation of Individuals During Normal Brain Aging.
Front Aging Neurosci
; 13: 711524, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34924992
12.
Multiscale causal networks identify VGF as a key regulator of Alzheimer's disease.
Nat Commun
; 11(1): 3942, 2020 08 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32770063
13.
Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models.
Cell Rep
; 32(2): 107908, 2020 07 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-32668255
14.
Intestinal epithelial Notch-1 protects from colorectal mucinous adenocarcinoma.
Oncotarget
; 9(71): 33536-33548, 2018 Sep 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30323897
15.
Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus.
Neuron
; 99(1): 64-82.e7, 2018 07 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-29937276
16.
Clarifying the Potential Role of Microbes in Alzheimer's Disease.
Neuron
; 104(6): 1036-1037, 2019 12 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-31855627
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