Búsqueda | Biblioteca Virtual en Salud

1.

Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer.

Bar-Peled, Liron; Kemper, Esther K; Suciu, Radu M; Vinogradova, Ekaterina V; Backus, Keriann M; Horning, Benjamin D; Paul, Thomas A; Ichu, Taka-Aki; Svensson, Robert U; Olucha, Jose; Chang, Max W; Kok, Bernard P; Zhu, Zhou; Ihle, Nathan T; Dix, Melissa M; Jiang, Ping; Hayward, Matthew M; Saez, Enrique; Shaw, Reuben J; Cravatt, Benjamin F.

Cell ; 171(3): 696-709.e23, 2017 Oct 19.

Artículo en Inglés | MEDLINE | ID: mdl-28965760

2.

Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes.

Schiemer, James; Horst, Reto; Meng, Yilin; Montgomery, Justin I; Xu, Yingrong; Feng, Xidong; Borzilleri, Kris; Uccello, Daniel P; Leverett, Carolyn; Brown, Stephen; Che, Ye; Brown, Matthew F; Hayward, Matthew M; Gilbert, Adam M; Noe, Mark C; Calabrese, Matthew F.

Nat Chem Biol ; 17(2): 152-160, 2021 02.

Artículo en Inglés | MEDLINE | ID: mdl-33199914

3.

Delineating the role of cooperativity in the design of potent PROTACs for BTK.

Zorba, Adelajda; Nguyen, Chuong; Xu, Yingrong; Starr, Jeremy; Borzilleri, Kris; Smith, James; Zhu, Hongyao; Farley, Kathleen A; Ding, WeiDong; Schiemer, James; Feng, Xidong; Chang, Jeanne S; Uccello, Daniel P; Young, Jennifer A; Garcia-Irrizary, Carmen N; Czabaniuk, Lara; Schuff, Brandon; Oliver, Robert; Montgomery, Justin; Hayward, Matthew M; Coe, Jotham; Chen, Jinshan; Niosi, Mark; Luthra, Suman; Shah, Jaymin C; El-Kattan, Ayman; Qiu, Xiayang; West, Graham M; Noe, Mark C; Shanmugasundaram, Veerabahu; Gilbert, Adam M; Brown, Matthew F; Calabrese, Matthew F.

Proc Natl Acad Sci U S A ; 115(31): E7285-E7292, 2018 07 31.

Artículo en Inglés | MEDLINE | ID: mdl-30012605

4.

Identification of Phosphorylation Consensus Sequences and Endogenous Neuronal Substrates of the Psychiatric Risk Kinase TNIK.

Wang, Qi; Amato, Stephen P; Rubitski, David M; Hayward, Matthew M; Kormos, Bethany L; Verhoest, Patrick R; Xu, Lan; Brandon, Nicholas J; Ehlers, Michael D.

J Pharmacol Exp Ther ; 356(2): 410-23, 2016 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-26645429

5.

A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors.

Lanning, Bryan R; Whitby, Landon R; Dix, Melissa M; Douhan, John; Gilbert, Adam M; Hett, Erik C; Johnson, Theodore O; Joslyn, Chris; Kath, John C; Niessen, Sherry; Roberts, Lee R; Schnute, Mark E; Wang, Chu; Hulce, Jonathan J; Wei, Baoxian; Whiteley, Laurence O; Hayward, Matthew M; Cravatt, Benjamin F.

Nat Chem Biol ; 10(9): 760-767, 2014 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-25038787

6.

Expanding the ligandable proteome by paralog hopping with covalent probes.

Zhang, Yuanjin; Liu, Zhonglin; Hirschi, Marsha; Brodsky, Oleg; Johnson, Eric; Won, Sang Joon; Nagata, Asako; Petroski, Matthew D; Majmudar, Jaimeen D; Niessen, Sherry; VanArsdale, Todd; Gilbert, Adam M; Hayward, Matthew M; Stewart, Al E; Nager, Andrew R; Melillo, Bruno; Cravatt, Benjamin.

bioRxiv ; 2024 Jan 19.

Artículo en Inglés | MEDLINE | ID: mdl-38293178

7.

Exploring aromatic chemical space with NEAT: novel and electronically equivalent aromatic template.

Tu, Meihua; Rai, Brajesh K; Mathiowetz, Alan M; Didiuk, Mary; Pfefferkorn, Jeffrey A; Guzman-Perez, Angel; Benbow, John; Guimarães, Cristiano R W; Mente, Scot; Hayward, Matthew M; Liras, Spiros.

J Chem Inf Model ; 52(5): 1114-23, 2012 May 25.

Artículo en Inglés | MEDLINE | ID: mdl-22486394

8.

A proteome-wide atlas of lysine-reactive chemistry.

Abbasov, Mikail E; Kavanagh, Madeline E; Ichu, Taka-Aki; Lazear, Michael R; Tao, Yongfeng; Crowley, Vincent M; Am Ende, Christopher W; Hacker, Stephan M; Ho, Jordan; Dix, Melissa M; Suciu, Radu; Hayward, Matthew M; Kiessling, Laura L; Cravatt, Benjamin F.

Nat Chem ; 13(11): 1081-1092, 2021 11.

Artículo en Inglés | MEDLINE | ID: mdl-34504315

9.

Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases.

Gerstenberger, Brian S; Ambler, Catherine; Arnold, Eric P; Banker, Mary-Ellen; Brown, Matthew F; Clark, James D; Dermenci, Alpay; Dowty, Martin E; Fensome, Andrew; Fish, Susan; Hayward, Matthew M; Hegen, Martin; Hollingshead, Brett D; Knafels, John D; Lin, David W; Lin, Tsung H; Owen, Dafydd R; Saiah, Eddine; Sharma, Raman; Vajdos, Felix F; Xing, Li; Yang, Xiaojing; Yang, Xin; Wright, Stephen W.

J Med Chem ; 63(22): 13561-13577, 2020 11 25.

Artículo en Inglés | MEDLINE | ID: mdl-32787094

10.

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841).

Fensome, Andrew; Ambler, Catherine M; Arnold, Eric; Banker, Mary Ellen; Brown, Matthew F; Chrencik, Jill; Clark, James D; Dowty, Martin E; Efremov, Ivan V; Flick, Andrew; Gerstenberger, Brian S; Gopalsamy, Ariamala; Hayward, Matthew M; Hegen, Martin; Hollingshead, Brett D; Jussif, Jason; Knafels, John D; Limburg, David C; Lin, David; Lin, Tsung H; Pierce, Betsy S; Saiah, Eddine; Sharma, Raman; Symanowicz, Peter T; Telliez, Jean-Baptiste; Trujillo, John I; Vajdos, Felix F; Vincent, Fabien; Wan, Zhao-Kui; Xing, Li; Yang, Xiaojing; Yang, Xin; Zhang, Liying.

J Med Chem ; 61(19): 8597-8612, 2018 10 11.

Artículo en Inglés | MEDLINE | ID: mdl-30113844

11.

Quantitative Chemical Proteomic Profiling of the in Vivo Targets of Reactive Drug Metabolites.

Whitby, Landon R; Obach, R Scott; Simon, Gabriel M; Hayward, Matthew M; Cravatt, Benjamin F.

ACS Chem Biol ; 12(8): 2040-2050, 2017 08 18.

Artículo en Inglés | MEDLINE | ID: mdl-28636309

12.

Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors.

Niessen, Sherry; Dix, Melissa M; Barbas, Sabrina; Potter, Zachary E; Lu, Shuyan; Brodsky, Oleg; Planken, Simon; Behenna, Douglas; Almaden, Chau; Gajiwala, Ketan S; Ryan, Kevin; Ferre, RoseAnn; Lazear, Michael R; Hayward, Matthew M; Kath, John C; Cravatt, Benjamin F.

Cell Chem Biol ; 24(11): 1388-1400.e7, 2017 Nov 16.

Artículo en Inglés | MEDLINE | ID: mdl-28965727

13.

Publisher Correction: A proteome-wide atlas of lysine-reactive chemistry.

Abbasov, Mikail E; Kavanagh, Madeline E; Ichu, Taka-Aki; Lazear, Michael R; Tao, Yongfeng; Crowley, Vincent M; Am Ende, Christopher W; Hacker, Stephan M; Ho, Jordan; Dix, Melissa M; Suciu, Radu; Hayward, Matthew M; Kiessling, Laura L; Cravatt, Benjamin F.

Nat Chem ; 13(11): 1151, 2021 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-34588639

14.

Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family.

Huard, Kim; Gosset, James R; Montgomery, Justin I; Gilbert, Adam; Hayward, Matthew M; Magee, Thomas V; Cabral, Shawn; Uccello, Daniel P; Bahnck, Kevin; Brown, Janice; Purkal, Julie; Gorgoglione, Matthew; Lanba, Adhiraj; Futatsugi, Kentaro; Herr, Michael; Genung, Nathan E; Aspnes, Gary; Polivkova, Jana; Garcia-Irizarry, Carmen N; Li, Qifang; Canterbury, Daniel; Niosi, Mark; Vera, Nicholas B; Li, Zhenhong; Khunte, Bhagyashree; Siderewicz, Jaclyn; Rolph, Timothy; Erion, Derek M.

J Med Chem ; 59(3): 1165-75, 2016 Feb 11.

Artículo en Inglés | MEDLINE | ID: mdl-26734723

15.

Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor.

Henderson, Jaclyn L; Kormos, Bethany L; Hayward, Matthew M; Coffman, Karen J; Jasti, Jayasankar; Kurumbail, Ravi G; Wager, Travis T; Verhoest, Patrick R; Noell, G Stephen; Chen, Yi; Needle, Elie; Berger, Zdenek; Steyn, Stefanus J; Houle, Christopher; Hirst, Warren D; Galatsis, Paul.

J Med Chem ; 58(1): 419-32, 2015 Jan 08.

Artículo en Inglés | MEDLINE | ID: mdl-25353650

16.

Chemical and computational methods for the characterization of covalent reactive groups for the prospective design of irreversible inhibitors.

Flanagan, Mark E; Abramite, Joseph A; Anderson, Dennis P; Aulabaugh, Ann; Dahal, Upendra P; Gilbert, Adam M; Li, Chao; Montgomery, Justin; Oppenheimer, Stacey R; Ryder, Tim; Schuff, Brandon P; Uccello, Daniel P; Walker, Gregory S; Wu, Yan; Brown, Matthew F; Chen, Jinshan M; Hayward, Matthew M; Noe, Mark C; Obach, R Scott; Philippe, Laurence; Shanmugasundaram, Veerabahu; Shapiro, Michael J; Starr, Jeremy; Stroh, Justin; Che, Ye.

J Med Chem ; 57(23): 10072-9, 2014 Dec 11.

Artículo en Inglés | MEDLINE | ID: mdl-25375838

17.

Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia.

Dounay, Amy B; Anderson, Marie; Bechle, Bruce M; Campbell, Brian M; Claffey, Michelle M; Evdokimov, Artem; Evrard, Edelweiss; Fonseca, Kari R; Gan, Xinmin; Ghosh, Somraj; Hayward, Matthew M; Horner, Weldon; Kim, Ji-Young; McAllister, Laura A; Pandit, Jayvardhan; Paradis, Vanessa; Parikh, Vinod D; Reese, Matthew R; Rong, SuoBao; Salafia, Michelle A; Schuyten, Katherine; Strick, Christine A; Tuttle, Jamison B; Valentine, James; Wang, Hong; Zawadzke, Laura E; Verhoest, Patrick R.

ACS Med Chem Lett ; 3(3): 187-92, 2012 Mar 08.

Artículo en Inglés | MEDLINE | ID: mdl-24900455

18.

Piperazinyl CCR1 antagonists--optimization of human liver microsome stability.

Brown, Matthew F; Bahnck, Kevin B; Blumberg, Laura C; Brissette, William H; Burrell, Sara A; Driscoll, James P; Fedeles, Flavia; Fisher, Michael B; Foti, Robert S; Gladue, Ronald P; Guzman-Martinez, Aikomari; Hayward, Matthew M; Lira, Paul D; Lillie, Brett M; Lu, Yi; Lundquist, Greg D; McElroy, Eric B; McGlynn, Molly A; Paradis, Timothy J; Poss, Christopher S; Roache, James H; Shavnya, Andrei; Shepard, Richard M; Trevena, Kristen A; Tylaska, Laurie A.

Bioorg Med Chem Lett ; 17(11): 3109-12, 2007 Jun 01.

Artículo en Inglés | MEDLINE | ID: mdl-17383873

19.

Lead-Seeking Approaches

Hayward, Matthew M.

Berlin, Heidelberg; Springer Berlin Heidelberg; 2010. 217 p.

Monografía en Inglés | Bibliografia | ID: bib-353015

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