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1.
Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1.
J Med Chem
; 66(7): 4888-4909, 2023 04 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-36940470
2.
Identification of novel pyrrolopyrazoles as protein kinase C ß II inhibitors.
Bioorg Med Chem Lett
; 21(1): 584-7, 2011 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21084194
3.
Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19.
J Med Chem
; 63(21): 12725-12747, 2020 11 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33054210
4.
Pyridones as glucokinase activators: identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle.
Bioorg Med Chem Lett
; 19(12): 3247-52, 2009 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19435665
5.
Palladium(ii)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids.
Chem Sci
; 9(44): 8363-8368, 2018 Nov 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-30542583
6.
Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations.
J Med Chem
; 57(11): 4720-44, 2014 Jun 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-24819116
7.
Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib.
J Med Chem
; 57(4): 1170-87, 2014 Feb 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-24432909
8.
Steady-state and pre-steady-state kinetic evaluation of severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro cysteine protease: development of an ion-pair model for catalysis.
Biochemistry
; 47(8): 2617-30, 2008 Feb 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-18237196
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