Detalles de la búsqueda
1.
Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation.
Bioorg Med Chem Lett
; 23(4): 1114-9, 2013 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23260349
2.
Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: use of a conformation-based hypothesis to facilitate compound design.
Bioorg Med Chem Lett
; 23(4): 1120-6, 2013 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23298810
3.
Acidic triazoles as soluble guanylate cyclase stimulators.
Bioorg Med Chem Lett
; 21(21): 6515-8, 2011 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21924901
4.
Modifications of C-2 on the pyrroloquinoline template aimed at the development of potent herpesvirus antivirals with improved aqueous solubility.
Bioorg Med Chem Lett
; 20(10): 3039-42, 2010 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20403696
5.
Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.
J Med Chem
; 61(23): 10415-10439, 2018 12 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-30130103
6.
Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases.
J Med Chem
; 61(3): 1130-1152, 2018 02 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29298069
7.
Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5).
J Med Chem
; 53(6): 2656-60, 2010 Mar 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-20196613
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