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1.
Intratracheal and oral administration of SM-276001: a selective TLR7 agonist, leads to antitumor efficacy in primary and metastatic models of cancer.
Int J Cancer
; 132(3): 580-90, 2013 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22733292
2.
Preclinical evaluation of M30 and M65 ELISAs as biomarkers of drug induced tumor cell death and antitumor activity.
Mol Cancer Ther
; 7(3): 455-63, 2008 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-18347133
3.
Synthesis and SAR of 1-acetanilide-4-aminopyrazole-substituted quinazolines: selective inhibitors of Aurora B kinase with potent anti-tumor activity.
Bioorg Med Chem Lett
; 18(6): 1904-9, 2008 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18294849
4.
AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis.
Clin Cancer Res
; 13(12): 3682-8, 2007 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17575233
5.
Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase.
J Med Chem
; 50(9): 2213-24, 2007 May 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-17373783
6.
Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors.
J Med Chem
; 49(3): 955-70, 2006 Feb 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-16451062
7.
Novel pharmacodynamic biomarkers for MYCN protein and PI3K/AKT/mTOR pathway signaling in children with neuroblastoma.
Mol Oncol
; 10(4): 538-52, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-26686971
8.
Interrogating two schedules of the AKT inhibitor MK-2206 in patients with advanced solid tumors incorporating novel pharmacodynamic and functional imaging biomarkers.
Clin Cancer Res
; 20(22): 5672-85, 2014 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25239610
9.
AT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity.
Clin Cancer Res
; 18(14): 3912-23, 2012 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22781553
10.
First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors.
J Clin Oncol
; 29(35): 4688-95, 2011 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-22025163
11.
Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930.
Mol Cancer Ther
; 10(2): 360-71, 2011 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-21191045
12.
AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth.
Mol Cancer Ther
; 9(5): 1100-10, 2010 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-20423992
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