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1.
Characterization of the Onset, Progression, and Reversibility of Morphological Changes in Mouse Lung after Pharmacological Inhibition of Leucine-Rich Kinase 2 Kinase Activity.
J Pharmacol Exp Ther
; 377(1): 11-19, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33509901
2.
Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease.
J Med Chem
; 66(21): 14912-14927, 2023 11 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37861679
3.
Ileocolonic-Targeted JAK Inhibitor: A Safer and More Effective Treatment for Inflammatory Bowel Disease.
Pharmaceutics
; 14(11)2022 Nov 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36365202
4.
Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors.
J Med Chem
; 65(1): 838-856, 2022 01 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-34967623
5.
Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease.
J Med Chem
; 65(24): 16801-16817, 2022 12 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-36475697
6.
Concomitant angiotensin AT1 receptor antagonism and neprilysin inhibition produces omapatrilat-like antihypertensive effects without promoting tracheal plasma extravasation in the rat.
J Cardiovasc Pharmacol
; 57(4): 495-504, 2011 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-21297495
7.
Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors.
RSC Med Chem
; 12(7): 1164-1173, 2021 Jul 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-34355182
8.
Discovery of N-(Indazol-3-yl)piperidine-4-carboxylic Acids as RORγt Allosteric Inhibitors for Autoimmune Diseases.
ACS Med Chem Lett
; 11(2): 114-119, 2020 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-32071676
9.
The role of melanin-concentrating hormone-1 receptors in the voiding reflex in rats.
J Pharmacol Exp Ther
; 328(1): 165-73, 2009 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-18849359
10.
The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity.
J Pharmacol Exp Ther
; 328(3): 900-11, 2009 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-19098165
11.
Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI).
ACS Med Chem Lett
; 10(1): 86-91, 2019 Jan 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-30655952
12.
Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists Part 1. The discovery of arylacetamides as viable replacements for the dihydropyrimidinone moiety of an HTS hit.
J Med Chem
; 50(16): 3870-82, 2007 Aug 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-17668921
13.
Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key fragments of HTS hits.
J Med Chem
; 50(16): 3883-90, 2007 Aug 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-17668922
14.
Comparative in vivo uroselectivity profiles of anticholinergics, tested in a novel anesthetized rabbit model.
Eur J Pharmacol
; 572(2-3): 207-12, 2007 Oct 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-17610864
15.
Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity.
Cell Rep
; 17(12): 3206-3218, 2016 12 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-28009290
16.
The effects of stressful stimuli and hypothalamic-pituitary-adrenal axis activation are reversed by the melanin-concentrating hormone 1 receptor antagonist SNAP 94847 in rodents.
Behav Brain Res
; 197(2): 284-91, 2009 Feb 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-18793675
17.
RBx 6198: a novel alpha1-adrenoceptor antagonist for the treatment of benign prostatic hyperplasia.
Eur J Pharmacol
; 607(1-3): 213-9, 2009 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19239913
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