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1.
Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms.
Arch Toxicol
; 92(2): 557-569, 2018 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-29362863
2.
Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation.
Hepatology
; 64(5): 1743-1756, 2016 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27532775
3.
Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates.
Chem Res Toxicol
; 29(12): 1936-1955, 2016 12 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-27661221
4.
Human NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated inactivation of reactive quinoneimine metabolites of diclofenac and mefenamic acid.
Chem Res Toxicol
; 27(4): 576-86, 2014 Apr 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-24552538
5.
Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three-Dimensional Spheroid Cultures of Primary Human Hepatocytes.
Clin Pharmacol Ther
; 108(4): 844-855, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32320483
6.
Human Liver Spheroids as a Model to Study Aetiology and Treatment of Hepatic Fibrosis.
Cells
; 9(4)2020 04 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-32295224
7.
New approach methodologies (NAMs) for human-relevant biokinetics predictions. Meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment
ALTEX
; 37(4): 607-622, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32521035
8.
3D Primary Hepatocyte Culture Systems for Analyses of Liver Diseases, Drug Metabolism, and Toxicity: Emerging Culture Paradigms and Applications.
Biotechnol J
; 14(7): e1800347, 2019 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-30957976
9.
Mechanisms of Chronic Fialuridine Hepatotoxicity as Revealed in Primary Human Hepatocyte Spheroids.
Toxicol Sci
; 171(2): 385-395, 2019 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31505000
10.
Inter-individual differences in the susceptibility of primary human hepatocytes towards drug-induced cholestasis are compound and time dependent.
Toxicol Lett
; 295: 187-194, 2018 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29913214
11.
Three-Dimensional Spheroid Primary Human Hepatocytes in Monoculture and Coculture with Nonparenchymal Cells.
Tissue Eng Part C Methods
; 24(9): 534-545, 2018 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30101670
12.
Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability.
Sci Rep
; 6: 35434, 2016 10 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-27759057
13.
Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease.
Sci Rep
; 6: 25187, 2016 05 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-27143246
14.
Expression and Function of mARC: Roles in Lipogenesis and Metabolic Activation of Ximelagatran.
PLoS One
; 10(9): e0138487, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26378779
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