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1.
The Single Toxin Origin of Alzheimer's Disease and Other Neurodegenerative Disorders Enables Targeted Approach to Treatment and Prevention.
Int J Mol Sci
; 25(5)2024 Feb 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-38473975
2.
Pharmacological evaluation of selective α2c-adrenergic agonists in experimental animal models of nasal congestion.
J Pharmacol Exp Ther
; 349(1): 75-84, 2014 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-24492651
3.
Synthesis and SAR studies of benzimidazolone derivatives as histamine H3-receptor antagonists.
Bioorg Med Chem Lett
; 23(21): 6001-3, 2013 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24050887
4.
Pharmacological characterization of a novel α2C-adrenoceptor agonist N-[3,4-dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1, 4-benzoxazin-6-yl]-N-ethyl-N'-methylurea (compound A).
J Pharmacol Exp Ther
; 337(1): 256-66, 2011 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-21233198
5.
The synthesis and structure-activity relationship of 4-benzimidazolyl-piperidinylcarbonyl-piperidine analogs as histamine H3 antagonists.
Bioorg Med Chem Lett
; 20(17): 5004-8, 2010 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20685118
6.
Aducanumab, gantenerumab, BAN2401, and ALZ-801-the first wave of amyloid-targeting drugs for Alzheimer's disease with potential for near term approval.
Alzheimers Res Ther
; 12(1): 95, 2020 08 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-32787971
7.
APOE ε4/ε4 homozygotes with early Alzheimer's disease show accelerated hippocampal atrophy and cortical thinning that correlates with cognitive decline.
Alzheimers Dement (N Y)
; 6(1): e12117, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-33304988
8.
Structural determinants for histamine H(1) affinity, hERG affinity and QTc prolongation in a series of terfenadine analogs.
Bioorg Med Chem Lett
; 19(17): 5043-7, 2009 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19660947
9.
Effect of a novel NOP receptor agonist (SCH 225288) on guinea pig irritant-evoked, feline mechanically induced and canine infectious tracheobronchitis cough.
Pharmacology
; 84(3): 153-61, 2009.
Artículo
en Inglés
| MEDLINE | ID: mdl-19696521
10.
Correction to: Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ-801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain.
CNS Drugs
; 32(12): 1185, 2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30421245
11.
Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ-801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain.
CNS Drugs
; 32(9): 849-861, 2018 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30076539
12.
Clinical Pharmacokinetics and Safety of ALZ-801, a Novel Prodrug of Tramiprosate in Development for the Treatment of Alzheimer's Disease.
Clin Pharmacokinet
; 57(3): 315-333, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29063518
13.
Elucidating the Aß42 Anti-Aggregation Mechanism of Action of Tramiprosate in Alzheimer's Disease: Integrating Molecular Analytical Methods, Pharmacokinetic and Clinical Data.
CNS Drugs
; 31(6): 495-509, 2017 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-28435985
14.
Temporal profile of forced expiratory lung function in allergen-challenged Brown-Norway rats.
Eur J Pharmacol
; 540(1-3): 147-54, 2006 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16756974
15.
An enzyme-linked immunosorbent assay (ELISA) for the determination of mucin levels in bronchoalveolar lavage fluid.
J Pharmacol Toxicol Methods
; 53(2): 160-7, 2006.
Artículo
en Inglés
| MEDLINE | ID: mdl-16507438
16.
TRPV1 receptor: a target for the treatment of pain, cough, airway disease and urinary incontinence.
Drug News Perspect
; 18(3): 165-71, 2005 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-15915217
17.
Effect of combined histamine H1 and H3 receptor blockade on cutaneous microvascular permeability elicited by compound 48/80.
Life Sci
; 76(16): 1787-94, 2005 Mar 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-15698856
18.
Development and potential utility of dual and triple NK receptor antagonists.
Curr Top Med Chem
; 3(12): 1410-22, 2003.
Artículo
en Inglés
| MEDLINE | ID: mdl-12871172
19.
Tachykinin NK3 and NK1 receptor activation elicits secretion from porcine airway submucosal glands.
Br J Pharmacol
; 138(1): 254-60, 2003 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-12522097
20.
Anandamide induces cough in conscious guinea-pigs through VR1 receptors.
Br J Pharmacol
; 137(6): 831-6, 2002 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-12411414