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1.
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Nature
; 556(7699): 113-117, 2018 04 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29590092
2.
Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production.
J Biol Chem
; 296: 100169, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-33298526
3.
Novel iodinated quinazolinones bearing sulfonamide as new scaffold targeting radiation induced oxidative stress.
Bioorg Med Chem Lett
; 42: 128002, 2021 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33811990
4.
KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.
Proc Natl Acad Sci U S A
; 114(23): E4676-E4685, 2017 06 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-28533375
5.
KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy.
Brain
; 141(5): 1390-1403, 2018 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29538645
6.
NAD(P)H: quinone oxidoreductase 1 inducer activity of novel 4-aminoquinazoline derivatives.
J Enzyme Inhib Med Chem
; 31(6): 1369-74, 2016 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26796666
7.
Synthesis, molecular modeling and NAD(P)H:quinone oxidoreductase 1 inducer activity of novel 2-phenylquinazolin-4-amine derivatives.
J Enzyme Inhib Med Chem
; 31(6): 1612-8, 2016 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-27052554
8.
Synthesis and biological evaluation of novel 2-phenylquinazoline-4-amine derivatives: identification of 6-phenyl-8H-benzo[g]quinazolino[4,3-b]quinazolin-8-one as a highly potent inducer of NAD(P)H quinone oxidoreductase 1.
J Enzyme Inhib Med Chem
; 31(sup1): 34-39, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27033734
9.
Synthesis, molecular modeling and NAD(P)H:quinone oxidoreductase 1 inducer activity of novel cyanoenone and enone benzenesulfonamides.
J Enzyme Inhib Med Chem
; 29(6): 840-5, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-24417210
10.
Synthesis of (13) C2 (15) N2 -labeled anti-inflammatory and cytoprotective tricyclic bis(cyanoenone) ([(13) C2 (15) N2 ]-TBE-31) as an internal standard for quantification by stable isotope dilution LC-MS method.
J Labelled Comp Radiopharm
; 57(10): 606-10, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-25196444
11.
Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways.
Nat Commun
; 15(1): 4096, 2024 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38750019
12.
Synthesis and biological evaluation of biotin conjugates of (±)-(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydro-phenanthrene-2,6-dicarbonitrile, an activator of the Keap1/Nrf2/ARE pathway, for the isolation of its protein targets.
Bioorg Med Chem Lett
; 23(20): 5540-3, 2013 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24018193
13.
NAD(P)H : quinone oxidoreductase 1 inducer activity of some Saudi Arabian medicinal plants.
Planta Med
; 79(6): 459-64, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23512501
14.
Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins.
Bioorg Med Chem
; 20(5): 1779-93, 2012 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22304848
15.
Pirin, an Nrf2-Regulated Protein, Is Overexpressed in Human Colorectal Tumors.
Antioxidants (Basel)
; 11(2)2022 Jan 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-35204145
16.
Biotinylation of an acetylenic tricyclic bis(cyanoenone) lowers its potency as an NRF2 activator while creating a novel activity against BACH1.
Free Radic Biol Med
; 191: 203-211, 2022 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36084789
17.
The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2.
iScience
; 25(1): 103703, 2022 Jan 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-35036882
18.
Phenyl Bis-Sulfonamide Keap1-Nrf2 Protein-Protein Interaction Inhibitors with an Alternative Binding Mode.
J Med Chem
; 65(10): 7380-7398, 2022 05 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-35549469
19.
The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, promote nuclear exclusion of BACH1 impairing its activity.
Redox Biol
; 51: 102291, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35313207
20.
Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response.
iScience
; 25(2): 103827, 2022 Feb 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-35198887