Detalles de la búsqueda
1.
Experiences and Translatability of In Vitro and In Vivo Models to Evaluate Caprate as a Permeation Enhancer.
Mol Pharm
; 21(1): 313-324, 2024 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-38054599
2.
Metabolism and Excretion of Therapeutic Peptides: Current Industry Practices, Perspectives, and Recommendations.
Drug Metab Dispos
; 51(11): 1436-1450, 2023 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-37591731
3.
In Vitro Assessment of the Drug-Drug Interaction Potential of Verinurad and Its Metabolites as Substrates and Inhibitors of Metabolizing Enzymes and Drug Transporters.
J Pharmacol Exp Ther
; 378(2): 108-123, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34074714
4.
Structural and conformational determinants of macrocycle cell permeability.
Nat Chem Biol
; 12(12): 1065-1074, 2016 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-27748751
5.
In Vitro Intrinsic Permeability: A Transporter-Independent Measure of Caco-2 Cell Permeability in Drug Design and Development.
Mol Pharm
; 14(5): 1601-1609, 2017 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28329446
6.
Tenapanor administration and the activity of the H+ -coupled transporter PepT1 in healthy volunteers.
Br J Clin Pharmacol
; 83(9): 2008-2014, 2017 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-28432691
7.
Erratum: Structural and conformational determinants of macrocycle cell permeability.
Nat Chem Biol
; 13(8): 922, 2017 Jul 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-28853740
8.
Cationic uremic toxins affect human renal proximal tubule cell functioning through interaction with the organic cation transporter.
Pflugers Arch
; 465(12): 1701-14, 2013 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-23812163
9.
Utility of in vitro systems and preclinical data for the prediction of human intestinal first-pass metabolism during drug discovery and preclinical development.
Drug Metab Dispos
; 41(12): 2033-46, 2013 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-23918667
10.
Resolving the distribution-metabolism interplay of eight OATP substrates in the standard clearance assay with suspended human cryopreserved hepatocytes.
Mol Pharm
; 10(12): 4443-51, 2013 Dec 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-24102095
11.
Industry Perspective on Therapeutic Peptide Drug-Drug Interaction Assessments During Drug Development: A European Federation of Pharmaceutical Industries and Associations White Paper.
Clin Pharmacol Ther
; 113(6): 1199-1216, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-36633114
12.
Characterization of THLE-cytochrome P450 (P450) cell lines: gene expression background and relationship to P450-enzyme activity.
Drug Metab Dispos
; 40(11): 2054-8, 2012 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-22851615
13.
Development of a highly sensitive method using liquid chromatography-multiple reaction monitoring to quantify membrane P-glycoprotein in biological matrices and relationship to transport function.
Drug Metab Dispos
; 39(12): 2440-9, 2011 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-21949244
14.
Primary Human Hepatocyte Spheroid Model as a 3D In Vitro Platform for Metabolism Studies.
J Pharm Sci
; 110(1): 422-431, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33122050
15.
High-activity p-glycoprotein, multidrug resistance protein 2, and breast cancer resistance protein membrane vesicles prepared from transiently transfected human embryonic kidney 293-epstein-barr virus nuclear antigen cells.
Drug Metab Dispos
; 38(4): 705-14, 2010 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-20071452
16.
Industrial Approach to Determine the Relative Contribution of Seven Major UGT Isoforms to Hepatic Glucuronidation.
J Pharm Sci
; 109(7): 2309-2320, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32294459
17.
Endogenous gene and protein expression of drug-transporting proteins in cell lines routinely used in drug discovery programs.
Drug Metab Dispos
; 37(12): 2275-83, 2009 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-19741037
18.
Modeling of drug-transporter interactions using structural information.
Curr Opin Drug Discov Devel
; 11(1): 95-103, 2008 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-18175272
19.
Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories.
Eur J Pharm Sci
; 35(5): 383-96, 2008 Dec 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-18782614
20.
Mass Spectrometry Imaging proves differential absorption profiles of well-characterised permeability markers along the crypt-villus axis.
Sci Rep
; 7(1): 6352, 2017 07 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-28743866