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1.
A Pharmacokinetic Modeling Approach to Predict the Contribution of Active Metabolites to Human Efficacious Dose.
Drug Metab Dispos
; 44(8): 1435-40, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27260151
2.
Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers.
J Med Chem
; 61(22): 10155-10172, 2018 11 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-30339381
3.
Preclinical Experimental and Mathematical Approaches for Assessing Effective Doses of Inhaled Drugs, Using Mometasone to Support Human Dose Predictions.
J Aerosol Med Pulm Drug Deliv
; 29(4): 362-77, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-26859446
4.
Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure-Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program.
J Med Chem
; 59(5): 1818-29, 2016 Mar 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26871940
5.
Discovery of 1-(1H-Pyrazolo[4,3-c]pyridin-6-yl)urea Inhibitors of Extracellular Signal-Regulated Kinase (ERK) for the Treatment of Cancers.
J Med Chem
; 59(13): 6501-11, 2016 07 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-27329786
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