Detalles de la búsqueda
1.
Nonclinical Cardiovascular Assessment of the Soluble Guanylate Cyclase Stimulator Vericiguat.
J Pharmacol Exp Ther
; 386(1): 26-34, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37068911
2.
A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm.
Toxicol Appl Pharmacol
; 394: 114961, 2020 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32209365
3.
Corrigendum to "A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm" [Toxicology and Applied Pharmacology volume 394C (2020) 114961].
Toxicol Appl Pharmacol
; 395: 114983, 2020 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32247767
4.
No Influence of Asundexian on Cardiac Repolarization.
Clin Pharmacol Drug Dev
; 13(3): 265-280, 2024 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-38224232
5.
Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839.
J Med Chem
; 67(2): 1225-1242, 2024 Jan 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-38228402
6.
Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective.
Clin Pharmacol Ther
; 109(2): 310-318, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-32866317
7.
Publisher Correction: Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells.
Sci Rep
; 10(1): 11884, 2020 Jul 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-32665705
8.
Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells.
Sci Rep
; 10(1): 5627, 2020 03 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-32221320
9.
Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5.
J Med Chem
; 62(2): 928-940, 2019 01 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-30563338
10.
Mechanisms involved in cardiac sensitization by volatile anesthetics: general applicability to halogenated hydrocarbons?
Crit Rev Toxicol
; 38(9): 773-803, 2008.
Artículo
en Inglés
| MEDLINE | ID: mdl-18941968
11.
Suitability of commonly used excipients for electrophysiological in-vitro safety pharmacology assessment of effects on hERG potassium current and on rabbit Purkinje fiber action potential.
J Pharmacol Toxicol Methods
; 56(2): 145-58, 2007.
Artículo
en Inglés
| MEDLINE | ID: mdl-17590357
12.
Safety pharmacology assessment of drug-induced QT-prolongation in dogs with reduced repolarization reserve.
J Pharmacol Toxicol Methods
; 54(2): 130-40, 2006.
Artículo
en Inglés
| MEDLINE | ID: mdl-16757186
13.
The "induced hyperactivity" test for the de-risking of potential off-target activity of antihypertensive drugs.
J Pharmacol Toxicol Methods
; 81: 313-22, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27179911
14.
Sphingosylphosphorylcholine-biological functions and mechanisms of action.
Biochim Biophys Acta
; 1582(1-3): 178-89, 2002 May 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-12069827
15.
Subsensitivity of P2X but not vanilloid 1 receptors in dorsal root ganglia of rats caused by cyclophosphamide cystitis.
Eur J Pharmacol
; 474(1): 71-5, 2003 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-12909197
16.
Drug-induced functional cardiotoxicity screening in stem cell-derived human and mouse cardiomyocytes: effects of reference compounds.
J Pharmacol Toxicol Methods
; 68(1): 97-111, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-23702537
17.
Field and action potential recordings in heart slices: correlation with established in vitro and in vivo models.
Br J Pharmacol
; 166(1): 276-96, 2012 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-22074238
18.
Introduction of a modular automated voltage-clamp platform and its correlation with manual human Ether-à-go-go related gene voltage-clamp data.
Assay Drug Dev Technol
; 9(6): 600-7, 2011 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-21675869
19.
QTc shortening with a new investigational cancer drug: a brief case study.
J Pharmacol Toxicol Methods
; 62(1): 72-81, 2010.
Artículo
en Inglés
| MEDLINE | ID: mdl-20570746
20.
Safety pharmacology assessment of central nervous system function in juvenile and adult rats: effects of pharmacological reference compounds.
J Pharmacol Toxicol Methods
; 58(2): 129-46, 2008.
Artículo
en Inglés
| MEDLINE | ID: mdl-18585470