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1.
Prolyl-tRNA synthetase inhibition promotes cell death in SK-MEL-2 cells through GCN2-ATF4 pathway activation.
Biochem Biophys Res Commun
; 488(4): 648-654, 2017 07 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28087278
2.
Design and synthesis of selective CDK8/19 dual inhibitors: Discovery of 4,5-dihydrothieno[3',4':3,4]benzo[1,2-d]isothiazole derivatives.
Bioorg Med Chem
; 25(8): 2336-2350, 2017 04 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28302507
3.
Studies of CDK 8/19 inhibitors: Discovery of novel and selective CDK8/19 dual inhibitors and elimination of their CYP3A4 time-dependent inhibition potential.
Bioorg Med Chem
; 25(12): 3018-3033, 2017 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28392276
4.
Design and synthesis of fused bicyclic inhibitors targeting the L5 loop site of centromere-associated protein E.
Bioorg Med Chem Lett
; 26(17): 4296-300, 2016 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27476141
5.
Synthetic studies of centromere-associated protein-E (CENP-E) inhibitors: 1.Exploration of fused bicyclic core scaffolds using electrostatic potential map.
Bioorg Med Chem
; 21(17): 5488-502, 2013 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23816042
6.
Structure-based design, synthesis, and evaluation of imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyridine derivatives as novel dual c-Met and VEGFR2 kinase inhibitors.
Bioorg Med Chem
; 21(24): 7686-98, 2013 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24216091
7.
Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor.
Bioorg Med Chem
; 21(8): 2333-2345, 2013 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23498918
8.
Synthetic Studies on Centromere-Associated Protein-E (CENP-E) Inhibitors: 2. Application of Electrostatic Potential Map (EPM) and Structure-Based Modeling to Imidazo[1,2-a]pyridine Derivatives as Anti-Tumor Agents.
J Med Chem
; 58(20): 8036-53, 2015 Oct 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-26372373
9.
Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells.
Nat Commun
; 6: 7668, 2015 Jul 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-26144554
10.
Chemo- and regioselective preparation and reaction of a kinetic zinc enolate formed from a thiol ester and bis(iodozincio)methane.
Angew Chem Int Ed Engl
; 45(48): 8200-3, 2006 Dec 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-17103470
11.
Preparation of enolate-homoenolate species as (Z)-gamma-siloxyallylmetal equivalents: sequential 1,4-addition of bis(iodozincio)methane to 1,4-dicarbonylbutenes and cyclopropanation.
Angew Chem Int Ed Engl
; 44(21): 3293-6, 2005 May 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-15844119
12.
Nucleophilic cyclopropanation reaction with bis(iodozincio)methane by 1,4-addition to alpha,beta-unsaturated carbonyl compounds.
Chem Asian J
; 4(8): 1298-303, 2009 Aug 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-19533673
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