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1.
Design of rigid protein-protein interaction inhibitors enables targeting of undruggable Mcl-1.
Proc Natl Acad Sci U S A
; 120(21): e2221967120, 2023 05 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-37186857
2.
The structure of human GCN2 reveals a parallel, back-to-back kinase dimer with a plastic DFG activation loop motif.
Biochem J
; 477(1): 275-284, 2020 01 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-31868900
3.
Heteroarylamide smoothened inhibitors: Discovery of N-[2,4-dimethyl-5-(1-methylimidazol-4-yl)phenyl]-4-(2-pyridylmethoxy)benzamide (AZD8542) and N-[5-(1H-imidazol-2-yl)-2,4-dimethyl-phenyl]-4-(2- pyridylmethoxy)benzamide (AZD7254).
Bioorg Med Chem
; 28(2): 115227, 2020 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31862310
4.
Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain.
Nat Chem Biol
; 12(11): 931-936, 2016 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-27595327
5.
Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors.
Bioorg Med Chem Lett
; 24(7): 1820-4, 2014 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24631189
6.
Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO.
Bioorg Med Chem Lett
; 22(14): 4907-11, 2012 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22704236
7.
Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases.
Bioorg Med Chem Lett
; 22(14): 4599-604, 2012 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22727640
8.
Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement.
J Med Chem
; 64(20): 15189-15213, 2021 10 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-34647738
9.
Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies.
J Med Chem
; 63(24): 15564-15590, 2020 12 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-33306391
10.
Recent advances in the development of Mcl-1 inhibitors for cancer therapy.
Pharmacol Ther
; 198: 59-67, 2019 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30790641
11.
Free Ligand 1D NMR Conformational Signatures To Enhance Structure Based Drug Design of a Mcl-1 Inhibitor (AZD5991) and Other Synthetic Macrocycles.
J Med Chem
; 62(21): 9418-9437, 2019 11 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-31361481
12.
Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors.
J Med Chem
; 61(3): 1061-1073, 2018 02 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29301085
13.
Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia.
Nat Commun
; 9(1): 5341, 2018 12 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-30559424
14.
Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors.
ACS Med Chem Lett
; 8(2): 239-244, 2017 Feb 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28197319
15.
Correction to "Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors".
ACS Med Chem Lett
; 8(11): 1204, 2017 11 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-29152055
16.
Correction to "Free Ligand 1D NMR Conformational Signatures To Enhance Structure Based Drug Design of a Mcl-1 Inhibitor (AZD5991) and Other Synthetic Macrocycles".
J Med Chem
; 64(5): 2849, 2021 Mar 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-33646774
17.
Small molecule inhibitor of apoptosis proteins antagonists: a patent review.
Expert Opin Ther Pat
; 25(7): 755-74, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25980951
18.
Small peptides as ligands for catalytic asymmetric alkylations of olefins. Rational design of catalysts or of searches that lead to them?
Chem Commun (Camb)
; (16): 1779-85, 2004 Aug 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-15306882
19.
Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582).
J Med Chem
; 56(24): 9897-919, 2013 Dec 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-24320998
20.
Cu-catalyzed enantioselective conjugate additions of alkyl zinc reagents to unsaturated N-acyloxazolidinones promoted by a chiral triamide phosphane.
Angew Chem Int Ed Engl
; 42(11): 1276-9, 2003 Mar 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-12645063