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1.
Nanog increases focal adhesion kinase (FAK) promoter activity and expression and directly binds to FAK protein to be phosphorylated.
J Biol Chem
; 287(22): 18656-73, 2012 May 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-22493428
2.
Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth.
BMC Cancer
; 13: 342, 2013 Jul 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-23841915
3.
A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl)-3, 5, 7-triaza-1-azoniatricyclo [3.3.1.1(3,7)]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo.
Carcinogenesis
; 33(5): 1004-13, 2012 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-22402131
4.
Down-regulation of ALDH1A3, CD44 or MDR1 sensitizes resistant cancer cells to FAK autophosphorylation inhibitor Y15.
J Cancer Res Clin Oncol
; 141(9): 1613-31, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-25656374
5.
Focal adhesion kinase regulates expression of thioredoxin-interacting protein (TXNIP) in cancer cells.
Anticancer Agents Med Chem
; 14(1): 3-8, 2014 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23387972
6.
MiR-138 and MiR-135 directly target focal adhesion kinase, inhibit cell invasion, and increase sensitivity to chemotherapy in cancer cells.
Anticancer Agents Med Chem
; 14(1): 18-28, 2014 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23438844
7.
The microarray gene profiling analysis of glioblastoma cancer cells reveals genes affected by FAK inhibitor Y15 and combination of Y15 and temozolomide.
Anticancer Agents Med Chem
; 14(1): 9-17, 2014 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23387973
8.
Gene Expression Profiling Identifies Important Genes Affected by R2 Compound Disrupting FAK and P53 Complex.
Cancers (Basel)
; 6(1): 166-78, 2014 Jan 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-24452144
9.
Mitoxantrone targets the ATP-binding site of FAK, binds the FAK kinase domain and decreases FAK, Pyk-2, c-Src, and IGF-1R in vitro kinase activities.
Anticancer Agents Med Chem
; 13(4): 546-54, 2013 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-22292772
10.
A small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo.
Anticancer Agents Med Chem
; 13(4): 532-45, 2013 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-22292771
11.
Pharmacologic blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide.
Mol Cancer Ther
; 12(2): 162-72, 2013 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-23243059
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