Detalles de la búsqueda
1.
Minimizing higher-order aggregation maximizes iron mobilization by small molecules.
Nat Chem Biol
; 2024 Apr 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-38664586
2.
Nitric Oxide-Releasing Macromolecule Exhibits Broad-Spectrum Antifungal Activity and Utility as a Topical Treatment for Superficial Fungal Infections.
Antimicrob Agents Chemother
; 62(7)2018 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29760128
3.
The novel kinase inhibitor PRT062070 (Cerdulatinib) demonstrates efficacy in models of autoimmunity and B-cell cancer.
J Pharmacol Exp Ther
; 351(3): 538-48, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-25253883
4.
The selective SYK inhibitor P505-15 (PRT062607) inhibits B cell signaling and function in vitro and in vivo and augments the activity of fludarabine in chronic lymphocytic leukemia.
J Pharmacol Exp Ther
; 344(2): 378-87, 2013 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-23220742
5.
Specific inhibition of spleen tyrosine kinase suppresses leukocyte immune function and inflammation in animal models of rheumatoid arthritis.
J Pharmacol Exp Ther
; 340(2): 350-9, 2012 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-22040680
6.
Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor.
Bioorg Med Chem Lett
; 19(8): 2179-85, 2009 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19297154
7.
Andexanet alfa effectively reverses edoxaban anticoagulation effects and associated bleeding in a rabbit acute hemorrhage model.
PLoS One
; 13(3): e0195122, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29590221
8.
Safety, pharmacokinetics, and reversal of apixaban anticoagulation with andexanet alfa.
Blood Adv
; 1(21): 1827-1838, 2017 Sep 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-29296829
9.
Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors.
Cancer Res
; 62(13): 3729-35, 2002 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-12097282
10.
Inhibition of purified factor Xa amidolytic activity may not be predictive of inhibition of in vivo thrombosis: implications for identification of therapeutically active inhibitors.
Arterioscler Thromb Vasc Biol
; 23(6): 1098-104, 2003 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-12750119
11.
Identification of orally active, potent, and selective 4-piperazinylquinazolines as antagonists of the platelet-derived growth factor receptor tyrosine kinase family.
J Med Chem
; 45(17): 3772-93, 2002 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-12166950
12.
Discovery of novel 2,8-diazaspiro[4.5]decanes as orally active glycoprotein IIb-IIIa antagonists.
J Med Chem
; 47(8): 2037-61, 2004 Apr 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-15056002
13.
Absence of QTc prolongation with betrixaban: a randomized, double-blind, placebo- and positive-controlled thorough ECG study.
Expert Opin Pharmacother
; 14(1): 5-13, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23216423
14.
A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa.
Nat Med
; 19(4): 446-51, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23455714
15.
Identification of 4-piperazin-1-yl-quinazoline template based aryl and benzyl thioureas as potent, selective, and orally bioavailable inhibitors of platelet-derived growth factor (PDGF) receptor.
Bioorg Med Chem Lett
; 14(19): 4867-72, 2004 Oct 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-15341941
16.
Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors incorporating substituted biphenyl P4 motifs.
Bioorg Med Chem Lett
; 14(4): 983-7, 2004 Feb 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-15013006
17.
Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors with improved functional activity.
Bioorg Med Chem Lett
; 14(4): 989-93, 2004 Feb 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-15013007
18.
Design, synthesis and structure-activity relationships of benzoxazinone-based factor Xa inhibitors.
Bioorg Med Chem Lett
; 13(3): 561-6, 2003 Feb 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-12565972
19.
N,N-Dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)-benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines as potent factor Xa inhibitors.
Bioorg Med Chem Lett
; 14(9): 2073-8, 2004 May 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-15080981
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