Detalles de la búsqueda
1.
Discovery of a novel 2-spiroproline steroid mimetic scaffold for the potent inhibition of 11ß-HSD1.
Bioorg Med Chem Lett
; 73: 128884, 2022 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35835377
2.
Discovery of 1'-(1-phenylcyclopropane-carbonyl)-3H-spiro[isobenzofuran-1,3'-pyrrolidin]-3-one as a novel steroid mimetic scaffold for the potent and tissue-specific inhibition of 11ß-HSD1 using a scaffold-hopping approach.
Bioorg Med Chem Lett
; 69: 128782, 2022 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35537608
3.
INCB040093 Is a Novel PI3Kδ Inhibitor for the Treatment of B Cell Lymphoid Malignancies.
J Pharmacol Exp Ther
; 364(1): 120-130, 2018 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29127109
4.
The Janus kinase 2 inhibitor fedratinib inhibits thiamine uptake: a putative mechanism for the onset of Wernicke's encephalopathy.
Drug Metab Dispos
; 42(10): 1656-62, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-25063672
5.
Characterization of INCB086550: A Potent and Novel Small-Molecule PD-L1 Inhibitor.
Cancer Discov
; 12(6): 1482-1499, 2022 06 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-35254416
6.
Identification and characterization of INCB9471, an allosteric noncompetitive small-molecule antagonist of C-C chemokine receptor 5 with potent inhibitory activity against monocyte migration and HIV-1 infection.
J Pharmacol Exp Ther
; 338(1): 228-39, 2011 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-21459966
7.
Discovery of Pemigatinib: A Potent and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor.
J Med Chem
; 64(15): 10666-10679, 2021 08 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34269576
8.
A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade.
Nat Commun
; 12(1): 4445, 2021 07 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-34290245
9.
INCB054828 (pemigatinib), a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays activity against genetically defined tumor models.
PLoS One
; 15(4): e0231877, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32315352
10.
The Novel Bromodomain and Extraterminal Domain Inhibitor INCB054329 Induces Vulnerabilities in Myeloma Cells That Inform Rational Combination Strategies.
Clin Cancer Res
; 25(1): 300-311, 2019 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30206163
11.
Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle P1' permutations.
Bioorg Med Chem Lett
; 18(2): 560-4, 2008 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18068976
12.
Design and identification of selective HER-2 sheddase inhibitors via P1' manipulation and unconventional P2' perturbations to induce a molecular metamorphosis.
Bioorg Med Chem Lett
; 18(1): 159-63, 2008 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18036818
13.
Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.
J Med Chem
; 50(4): 603-6, 2007 Feb 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-17256836
14.
High-throughput determination of mode of inhibition in lead identification and optimization.
J Biomol Screen
; 12(2): 220-8, 2007 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-17351185
15.
Effects of a hospital-wide intervention on emergency department crowding and quality: A prospective study.
Emerg Med Australas
; 29(4): 415-420, 2017 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-28378942
16.
Prehospital ketamine use by paramedics in the Australian Capital Territory: A 12 month retrospective analysis.
Emerg Med Australas
; 29(1): 89-95, 2017 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-27699989
17.
Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells.
Cancer Biol Ther
; 5(6): 657-64, 2006 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-16627989
18.
Potent benzimidazole sulfonamide protein tyrosine phosphatase 1B inhibitors containing the heterocyclic (S)-isothiazolidinone phosphotyrosine mimetic.
J Med Chem
; 49(13): 3774-89, 2006 Jun 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-16789735
19.
Identification and characterization of antibodies that bind GPIIb/IIIa: antagonist complexes.
J Immunol Methods
; 301(1-2): 11-20, 2005 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-15992818
20.
Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics.
J Med Chem
; 48(21): 6544-8, 2005 Oct 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-16220970