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1.
Inhibition of mitochondrial LonP1 protease by allosteric blockade of ATP binding and hydrolysis via CDDO and its derivatives.
J Biol Chem
; 298(3): 101719, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-35151690
2.
Recent progress in the strategic incorporation of fluorine into medicinally active compounds.
J Fluor Chem
; 217: 29-40, 2019 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-31537946
3.
Synthesis of Colchicinoids and Allocolchicinoids through Rh(I)-Catalyzed [2+2+2+1] and [2+2+2] Cycloadditions of o-Phenylenetriynes with and without CO.
J Org Chem
; 83(19): 11623-11644, 2018 10 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30129760
4.
Synthesis of a Next-Generation Taxoid by Rapid Methylation Amenable for 11C-Labeling.
J Org Chem
; 83(5): 2847-2857, 2018 03 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29441783
5.
Design and synthesis of tumor-targeting theranostic drug conjugates for SPECT and PET imaging studies.
Bioorg Chem
; 76: 458-467, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29287255
6.
The acetylenic tricyclic bis(cyano enone), TBE-31, targets microtubule dynamics and cell polarity in migrating cells.
Biochim Biophys Acta
; 1863(4): 638-49, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-26775215
7.
Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer.
Br J Cancer
; 117(5): e1, 2017 Aug 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-28324888
8.
Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer.
Br J Cancer
; 115(12): 1530-1539, 2016 Dec 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-27824809
9.
Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme.
Bioorg Med Chem Lett
; 26(17): 4345-9, 2016 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27460172
10.
Inâ Situ Observation of Thiol Michael Addition to a Reversible Covalent Drug in a Crystalline Sponge.
Angew Chem Int Ed Engl
; 55(16): 4919-23, 2016 Apr 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-26970084
11.
Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action.
Biochem Biophys Res Commun
; 465(3): 402-7, 2015 Sep 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-26265043
12.
Targeting lipid peroxidation and mitochondrial imbalance in Friedreich's ataxia.
Pharmacol Res
; 99: 344-50, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-26141703
13.
Synthesis of (13) C2 (15) N2 -labeled anti-inflammatory and cytoprotective tricyclic bis(cyanoenone) ([(13) C2 (15) N2 ]-TBE-31) as an internal standard for quantification by stable isotope dilution LC-MS method.
J Labelled Comp Radiopharm
; 57(10): 606-10, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-25196444
14.
Acetylenic tricyclic bis-(cyano enone) interacts with Cys 374 of actin, a residue necessary for stress fiber formation and cell migration.
Biochim Biophys Acta Mol Cell Res
; 1871(2): 119629, 2024 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-37981034
15.
Inhibition of glycogen synthase kinase-3 enhances NRF2 protein stability, nuclear localisation and target gene transcription in pancreatic beta cells.
Redox Biol
; 71: 103117, 2024 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-38479223
16.
Synthesis and biological evaluation of biotin conjugates of (±)-(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydro-phenanthrene-2,6-dicarbonitrile, an activator of the Keap1/Nrf2/ARE pathway, for the isolation of its protein targets.
Bioorg Med Chem Lett
; 23(20): 5540-3, 2013 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24018193
17.
(±)-(4bS,8aR,10aS)-10a-Ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octa-hydro-phenanthrene-2,6-dicarbonitrile.
Acta Crystallogr Sect E Struct Rep Online
; 68(Pt 11): o3095-6, 2012 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23284424
18.
Pirin, an Nrf2-Regulated Protein, Is Overexpressed in Human Colorectal Tumors.
Antioxidants (Basel)
; 11(2)2022 Jan 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-35204145
19.
Biotinylation of an acetylenic tricyclic bis(cyanoenone) lowers its potency as an NRF2 activator while creating a novel activity against BACH1.
Free Radic Biol Med
; 191: 203-211, 2022 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36084789
20.
The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, promote nuclear exclusion of BACH1 impairing its activity.
Redox Biol
; 51: 102291, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35313207