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1.
Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.
Bioorg Med Chem Lett
; 24(24): 5630-5634, 2014 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25466188
2.
Discovery of Selective Pituitary Adenylate Cyclase 1 Receptor (PAC1R) Antagonist Peptides Potent in a Maxadilan/PACAP38-Induced Increase in Blood Flow Pharmacodynamic Model.
J Med Chem
; 64(6): 3427-3438, 2021 03 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-33715378
3.
Cytochrome P450-mediated epoxidation of 2-aminothiazole-based AKT inhibitors: identification of novel GSH adducts and reduction of metabolic activation through structural changes guided by in silico and in vitro screening.
Chem Res Toxicol
; 23(3): 653-63, 2010 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20095585
4.
Azole-based inhibitors of AKT/PKB for the treatment of cancer.
Bioorg Med Chem Lett
; 20(5): 1559-64, 2010 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20137943
5.
Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis.
J Med Chem
; 58(11): 4462-82, 2015 Jun 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-25914941
6.
Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N â S (nN â σ*S-X) Interaction for Conformational Constraint.
J Med Chem
; 58(24): 9663-79, 2015 Dec 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26551034
7.
Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors.
ACS Med Chem Lett
; 6(9): 987-92, 2015 Sep 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26396685
8.
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 4. Exploration of a novel binding pocket.
J Med Chem
; 57(14): 5949-64, 2014 Jul 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-25001129
9.
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles.
J Med Chem
; 57(2): 325-38, 2014 Jan 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-24405213
10.
Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases.
J Med Chem
; 55(11): 5188-219, 2012 Jun 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-22548365
11.
Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
J Med Chem
; 55(17): 7796-816, 2012 Sep 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-22897589
12.
Heteroatomic Effects on the Reducibility of C-2 Carbinol Centers in 6-Ethoxy-3,6-dihydropyrans and -thiopyrans.
J Org Chem
; 64(10): 3783-3786, 1999 May 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-11674519
13.
Total synthesis of dumsin. 1. Retrosynthetic strategy and the elaboration of key intermediates from (--)-bornyl acetate.
J Org Chem
; 68(18): 6905-18, 2003 Sep 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-12946130
14.
Stereocontrolled synthesis of triazacyclopenta[cd]pentalenes by intramolecular 1,3-dipolar cycloaddition reactions of azomethine imines.
J Org Chem
; 67(22): 7880-3, 2002 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-12398520
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