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1.
N-(2-Mercaptopropionyl)-glycine, a diffusible antioxidant, activates HIF-1 by inhibiting HIF prolyl hydroxylase-2: implication in amelioration of rat colitis by the antioxidant.
Biochem Biophys Res Commun
; 443(3): 1008-13, 2014 Jan 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-24361888
2.
Colon-targeted cell-permeable NFκB inhibitory peptide is orally active against experimental colitis.
Mol Pharm
; 9(5): 1310-9, 2012 May 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-22428658
3.
Structural effects of N-aromatic acyl-amino acid conjugates on their deconjugation in the cecal contents of rats: implication in design of a colon-specific prodrug with controlled conversion rate at the target site.
Biopharm Drug Dispos
; 32(6): 343-54, 2011 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-21800327
4.
Design and evaluation of IKK-activated GSK3ß inhibitory peptide as an inflammation-responsive anti-colitic therapeutic.
Biomater Sci
; 9(19): 6584-6596, 2021 Sep 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-34582526
5.
von Hippel-Lindau ß-domain-luciferase fusion protein as a bioluminescent hydroxyproline sensor for a hypoxia-inducible factor prolyl hydroxylase assay.
Anal Biochem
; 407(2): 220-5, 2010 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20705044
6.
Manganese (II) induces chemical hypoxia by inhibiting HIF-prolyl hydroxylase: implication in manganese-induced pulmonary inflammation.
Toxicol Appl Pharmacol
; 235(3): 261-7, 2009 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19263519
7.
Lipophilic modification enhances anti-colitic properties of rosmarinic acid by potentiating its HIF-prolyl hydroxylases inhibitory activity.
Eur J Pharmacol
; 747: 114-22, 2015 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25483211
8.
Colon-targeted celecoxib ameliorates TNBS-induced rat colitis: a potential pharmacologic mechanism and therapeutic advantages.
Eur J Pharmacol
; 726: 49-56, 2014 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-24462351
9.
Piceatannol, a hydroxystilbene natural product, stabilizes HIF-1α protein by inhibiting HIF prolyl hydroxylase.
Eur J Pharmacol
; 699(1-3): 124-31, 2013 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23261967
10.
Caffeic acid phenethyl ester activation of Nrf2 pathway is enhanced under oxidative state: structural analysis and potential as a pathologically targeted therapeutic agent in treatment of colonic inflammation.
Free Radic Biol Med
; 65: 552-562, 2013 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-23892357
11.
Structure-activity relationship of salicylic acid derivatives on inhibition of TNF-α dependent NFκB activity: Implication on anti-inflammatory effect of N-(5-chlorosalicyloyl)phenethylamine against experimental colitis.
Eur J Med Chem
; 48: 36-44, 2012 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-22154834
12.
Susceptibility of glucocorticoids to colonic metabolism and pharmacologic intervention in the metabolism: implication for therapeutic activity of colon-specific glucocorticoid 21-sulfate sodium at the target site.
J Pharm Pharmacol
; 64(1): 128-38, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-22150680
13.
Hyperoxia attenuates the inhibitory effect of nitric oxide donors on HIF prolyl-4-hydroxylase-2: Implication on discriminative effect of nitric oxide on HIF prolyl-4-hydroxylase-2 and collagen prolyl-4-hydroxylase.
Biochem Pharmacol
; 82(5): 485-90, 2011 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21723853
14.
Caffeic acid phenethyl ester is a potent inhibitor of HIF prolyl hydroxylase: structural analysis and pharmacological implication.
J Nutr Biochem
; 21(9): 809-17, 2010 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-19740641
15.
Caffeic acid phenethyl ester-mediated Nrf2 activation and IkappaB kinase inhibition are involved in NFkappaB inhibitory effect: structural analysis for NFkappaB inhibition.
Eur J Pharmacol
; 643(1): 21-8, 2010 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20599928
16.
Synthesis and evaluation of N-nicotinoyl-2-{2-(2-methyl-5-nitroimidazol-1-yl)ethyloxy}-D,L-glycine as a colon-specific prodrug of metronidazole.
J Pharm Sci
; 98(11): 4161-9, 2009 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-19283770
17.
Dexamethasone 21-sulfate improves the therapeutic properties of dexamethasone against experimental rat colitis by specifically delivering the steroid to the large intestine.
Pharm Res
; 26(2): 415-21, 2009 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-18958401
18.
An anti-inflammatory mechanism of taurine conjugated 5-aminosalicylic acid against experimental colitis: taurine chloramine potentiates inhibitory effect of 5-aminosalicylic acid on IL-1beta-mediated NFkappaB activation.
Eur J Pharmacol
; 618(1-3): 91-7, 2009 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19616541
19.
Sulfate-conjugated methylprednisolone as a colon-targeted methylprednisolone prodrug with improved therapeutic properties against rat colitis.
J Drug Target
; 17(6): 450-8, 2009 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-19527116
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