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1.
Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders.
Pharmacol Rev
; 74(3): 600-629, 2022 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35710131
2.
Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B.
Biochemistry
; 61(4): 228-238, 2022 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35119840
3.
Cathepsin B inhibition blocks neurite outgrowth in cultured neurons by regulating lysosomal trafficking and remodeling.
J Neurochem
; 155(3): 300-312, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32330298
4.
Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease.
Biochim Biophys Acta
; 1824(1): 89-104, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-21925292
5.
Cathepsin B Deficiency Improves Memory Deficits and Reduces Amyloid-ß in hAßPP Mouse Models Representing the Major Sporadic Alzheimer's Disease Condition.
J Alzheimers Dis
; 93(1): 33-46, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-36970896
6.
Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions.
ACS Chem Biol
; 16(9): 1628-1643, 2021 09 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-34416110
7.
Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce beta-amyloid related to Alzheimer's disease.
Biol Chem
; 391(8): 861-72, 2010 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-20536395
8.
Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders.
Biochim Biophys Acta Proteins Proteom
; 1868(8): 140428, 2020 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32305689
9.
Penetrating Traumatic Brain Injury Triggers Dysregulation of Cathepsin B Protein Levels Independent of Cysteine Protease Activity in Brain and Cerebral Spinal Fluid.
J Neurotrauma
; 37(13): 1574-1586, 2020 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31973644
10.
Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein.
Biochem Biophys Res Commun
; 386(2): 284-8, 2009 Aug 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-19501042
11.
Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate.
Front Neurol
; 6: 178, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26388830
12.
Brain pyroglutamate amyloid-ß is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeutic.
J Alzheimers Dis
; 41(1): 129-49, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24595198
13.
The cysteine protease cathepsin B is a key drug target and cysteine protease inhibitors are potential therapeutics for traumatic brain injury.
J Neurotrauma
; 31(5): 515-29, 2014 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24083575
14.
Deletion of the cathepsin B gene improves memory deficits in a transgenic ALZHeimer's disease mouse model expressing AßPP containing the wild-type ß-secretase site sequence.
J Alzheimers Dis
; 29(4): 827-40, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22337825
15.
The cysteine protease inhibitor, E64d, reduces brain amyloid-ß and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, ß-secretase activity.
J Alzheimers Dis
; 26(2): 387-408, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-21613740
16.
Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein.
J Biol Chem
; 283(12): 7745-53, 2008 Mar 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-18184658
17.
Alternative pathways for production of beta-amyloid peptides of Alzheimer's disease.
Biol Chem
; 389(8): 993-1006, 2008 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-18979625
18.
Cysteine protease inhibitors effectively reduce in vivo levels of brain beta-amyloid related to Alzheimer's disease.
Biol Chem
; 388(2): 247-52, 2007 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-17261088
19.
Cysteine protease inhibitors reduce brain beta-amyloid and beta-secretase activity in vivo and are potential Alzheimer's disease therapeutics.
Biol Chem
; 388(9): 979-83, 2007 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-17696783
20.
Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease.
Biol Chem
; 386(9): 931-40, 2005 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-16164418
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