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1.
Synthesis and structure-activity relationship of novel lactam-fused chroman derivatives having dual affinity at the 5-HT(1A) receptor and the serotonin transporter.
Bioorg Med Chem Lett
; 20(1): 222-7, 2010 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19932965
2.
Novel benzofuran derivatives with dual 5-HT1A receptor and serotonin transporter affinity.
Bioorg Med Chem Lett
; 20(3): 824-7, 2010 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20064720
3.
Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives.
Bioorg Med Chem
; 16(14): 6707-23, 2008 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18571421
4.
Synthesis and biological evaluation of novel compounds within a class of 3-aminochroman derivatives with dual 5-HT1A receptor and serotonin transporter affinity.
J Med Chem
; 49(15): 4785-9, 2006 Jul 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-16854086
5.
The effect of mGlu5 receptor positive allosteric modulators on signaling molecules in brain slices.
Eur J Pharmacol
; 536(3): 262-8, 2006 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16600209
6.
Synthesis and biological evaluation of benzodioxanylpiperazine derivatives as potent serotonin 5-HT(1A) antagonists: the discovery of Lecozotan.
J Med Chem
; 48(10): 3467-70, 2005 May 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-15887953
7.
Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines.
J Med Chem
; 47(15): 3823-42, 2004 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15239661
8.
Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists.
J Med Chem
; 52(15): 4955-9, 2009 Aug 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-19719241
9.
Advances toward new antidepressants with dual serotonin transporter and 5-HT1A receptor affinity within a class of 3-aminochroman derivatives. Part 2.
J Med Chem
; 51(21): 6980-7004, 2008 Nov 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-18834188
10.
Differential and synergistic effects of selective norepinephrine and serotonin reuptake inhibitors in rodent models of pain.
J Pharmacol Exp Ther
; 320(3): 1178-85, 2007 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-17142646
11.
Novel pyridyl-fused 3-amino chroman derivatives with dual action at serotonin transporter and 5-HT1A receptor.
Bioorg Med Chem Lett
; 17(11): 3117-21, 2007 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17407811
12.
Studies toward the discovery of the next generation of antidepressants. Part 5: 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives with dual 5-HT1A receptor and serotonin transporter affinity.
Bioorg Med Chem Lett
; 16(5): 1338-41, 2006 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16332439
13.
Studies towards the next generation of antidepressants. Part 4: derivatives of 4-(5-fluoro-1H-indol-3-yl)cyclohexylamine with affinity for the serotonin transporter and the 5-HT1A receptor.
Bioorg Med Chem Lett
; 15(4): 911-4, 2005 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15686885
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