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1.
7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment.
Molecules
; 20(12): 22084-101, 2015 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26690394
2.
A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice.
Toxicol Mech Methods
; 25(3): 229-33, 2015 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25894563
3.
The evaluation of the reactivating and therapeutic efficacy of two novel oximes (K361 and K378) in comparison with the oxime K203 and trimedoxime in tabun-poisoned rats and mice.
Toxicol Mech Methods
; 24(3): 173-8, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24295433
4.
Preparation, in vitro evaluation and molecular modelling of pyridinium-quinolinium/isoquinolinium non-symmetrical bisquaternary cholinesterase inhibitors.
Bioorg Med Chem Lett
; 23(24): 6663-6, 2013 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24220173
5.
7-Methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors in Alzheimer's disease treatment--synthesis, biological evaluation and molecular modeling studies.
Molecules
; 18(2): 2397-418, 2013 Feb 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-23429378
6.
The evaluation of the reactivating and therapeutic efficacy of three novel bispyridinium oximes (K454, K456, K458) in comparison with the oxime K203 and trimedoxime in tabun-poisoned rats and mice.
Toxicol Mech Methods
; 23(2): 94-8, 2013 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-22901042
7.
Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment.
Bioorg Med Chem Lett
; 21(8): 2505-9, 2011 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21397501
8.
Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties.
Bioorg Med Chem Lett
; 21(21): 6563-6, 2011 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21920739
9.
Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage-Preparation, in vitro screening and molecular docking.
Bioorg Med Chem
; 19(2): 754-62, 2011 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21215642
10.
Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings.
Drug Des Devel Ther
; 12: 505-512, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29563775
11.
A comparison of the reactivating and therapeutic efficacy of two newly developed oximes (k727 and k733) with oxime k203 and trimedoxime in tabun-poisoned rats and mice.
Basic Clin Pharmacol Toxicol
; 116(4): 367-71, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25225130
12.
Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity.
J Med Chem
; 58(22): 8985-9003, 2015 Nov 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-26503905
13.
Preparation, in vitro screening and molecular modelling of monoquaternary compounds related to the selective acetylcholinesterase inhibitor BW284c51.
Med Chem
; 11(1): 21-9, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24773345
14.
7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies.
Eur J Med Chem
; 82: 426-38, 2014 Jul 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-24929293
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