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1.
Intermittent oral coadministration of a gamma secretase inhibitor with dexamethasone mitigates intestinal goblet cell hyperplasia in rats.
Toxicol Pathol
; 42(2): 422-34, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-23651588
2.
N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11ß-hydroxysteroid dehydrogenase type 1: strategies to eliminate reactive metabolites.
Bioorg Med Chem Lett
; 23(8): 2344-8, 2013 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23489629
3.
Dose-dependent effects of small-molecule antagonists on the genomic landscape of androgen receptor binding.
BMC Genomics
; 13: 355, 2012 Jul 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-22849360
4.
Discovery of 3-aryloxy-lactam analogs as potent androgen receptor full antagonists for treating castration resistant prostate cancer.
Bioorg Med Chem Lett
; 22(2): 1230-6, 2012 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22197140
5.
The development and SAR of pyrrolidine carboxamide 11beta-HSD1 inhibitors.
Bioorg Med Chem Lett
; 20(9): 2897-902, 2010 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20363126
6.
Prediction of human pharmacokinetics from preclinical information: comparative accuracy of quantitative prediction approaches.
J Clin Pharmacol
; 49(5): 513-33, 2009 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-19299532
7.
N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275.
Bioorg Med Chem Lett
; 19(13): 3493-7, 2009 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19473839
8.
Demonstration of proof of mechanism and pharmacokinetics and pharmacodynamic relationship with 4'-cyano-biphenyl-4-sulfonic acid (6-amino-pyridin-2-yl)-amide (PF-915275), an inhibitor of 11 -hydroxysteroid dehydrogenase type 1, in cynomolgus monkeys.
J Pharmacol Exp Ther
; 324(1): 299-305, 2008 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-17921190
9.
Factors affecting the clinical development of cytochrome p450 3A substrates.
Clin Pharmacokinet
; 42(11): 969-84, 2003.
Artículo
en Inglés
| MEDLINE | ID: mdl-12908853
10.
Drug design tools--in silico, in vitro and in vivo ADME/PK prediction and interpretation: is PK in monkey an essential part of a good human PK prediction?
Curr Top Med Chem
; 11(4): 351-7, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-21320064
11.
Simulation of human intravenous and oral pharmacokinetics of 21 diverse compounds using physiologically based pharmacokinetic modelling.
Clin Pharmacokinet
; 50(5): 331-47, 2011 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-21456633
12.
Discovery of aryloxy tetramethylcyclobutanes as novel androgen receptor antagonists.
J Med Chem
; 54(21): 7693-704, 2011 Nov 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-21936524
13.
Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design.
Mol Cancer Ther
; 9(6): 1618-28, 2010 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-20530712
14.
Evaluation of cerebrospinal fluid concentration and plasma free concentration as a surrogate measurement for brain free concentration.
Drug Metab Dispos
; 34(9): 1443-7, 2006 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-16760229
15.
Use of a physiologically based pharmacokinetic model to study the time to reach brain equilibrium: an experimental analysis of the role of blood-brain barrier permeability, plasma protein binding, and brain tissue binding.
J Pharmacol Exp Ther
; 313(3): 1254-62, 2005 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-15743928
16.
The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model.
Drug Metab Dispos
; 33(1): 165-74, 2005 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-15502009
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