Detalles de la búsqueda
1.
Structural Characterization of 5-Substituted Pyrrolo[3,2-d]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2.
Biochemistry
; 2024 Feb 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-38324671
2.
The evolving biology of the proton-coupled folate transporter: New insights into regulation, structure, and mechanism.
FASEB J
; 36(2): e22164, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-35061292
3.
Folate transporter offers clues for anticancer drugs.
Nature
; 612(7938): 39-41, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36418878
4.
Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors.
Bioorg Med Chem
; 37: 116093, 2021 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33773393
5.
Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism.
Mol Pharmacol
; 97(1): 9-22, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31707355
6.
Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier.
Bioorg Med Chem
; 28(12): 115544, 2020 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32503687
7.
Regulation of differential proton-coupled folate transporter gene expression in human tumors: transactivation by KLF15 with NRF-1 and the role of Sp1.
Biochem J
; 476(8): 1247-1266, 2019 04 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-30914440
8.
Discovery of amide-bridged pyrrolo[2,3-d]pyrimidines as tumor targeted classical antifolates with selective uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis.
Bioorg Med Chem
; 27(23): 115125, 2019 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31679978
9.
Functional and mechanistic roles of the human proton-coupled folate transporter transmembrane domain 6-7 linker.
Biochem J
; 473(20): 3545-3562, 2016 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27514717
10.
Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.
Biochemistry
; 55(32): 4574-82, 2016 08 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-27439469
11.
Targeting Nonsquamous Nonsmall Cell Lung Cancer via the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]Pyrimidine Thienoyl Antifolates.
Mol Pharmacol
; 89(4): 425-34, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-26837243
12.
Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6.
Biochem J
; 469(1): 33-44, 2015 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25877470
13.
Substituted cysteine accessibility reveals a novel transmembrane 2-3 reentrant loop and functional role for transmembrane domain 2 in the human proton-coupled folate transporter.
J Biol Chem
; 289(36): 25287-95, 2014 Sep 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-25053408
14.
The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer.
Drug Metab Dispos
; 42(4): 632-49, 2014 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-24396145
15.
Biology of the major facilitative folate transporters SLC19A1 and SLC46A1.
Curr Top Membr
; 73: 175-204, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24745983
16.
Mitochondrial and Cytosolic One-Carbon Metabolism Is a Targetable Metabolic Vulnerability in Cisplatin-Resistant Ovarian Cancer.
Mol Cancer Ther
; 23(6): 809-822, 2024 Jun 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-38377173
17.
Enhancing anti-AML activity of venetoclax by isoflavone ME-344 through suppression of OXPHOS and/or purine biosynthesis in vitro.
Biochem Pharmacol
; 220: 115981, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-38081370
18.
Identification and functional impact of homo-oligomers of the human proton-coupled folate transporter.
J Biol Chem
; 287(7): 4982-95, 2012 Feb 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-22179615
19.
Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria.
J Med Chem
; 66(16): 11294-11323, 2023 08 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-37582241
20.
Multitargeted 6-Substituted Thieno[2,3-d]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon Metabolism.
ACS Pharmacol Transl Sci
; 6(5): 748-770, 2023 May 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37200803