Búsqueda | Biblioteca Virtual en Salud

1.

Impaired cathepsin D in retinal pigment epithelium cells mediates Stargardt disease pathogenesis.

Ng, Eunice Sze Yin; Hu, Jane; Jiang, Zhichun; Radu, Roxana A.

FASEB J ; 38(11): e23720, 2024 Jun 15.

Artículo en Inglés | MEDLINE | ID: mdl-38837708

2.

Regulatory mechanism for the transmembrane receptor that mediates bidirectional vitamin A transport.

Zhong, Ming; Kawaguchi, Riki; Costabile, Brianna; Tang, Yuyan; Hu, Jane; Cheng, Guo; Kassai, Miki; Ribalet, Bernard; Mancia, Filippo; Bok, Dean; Sun, Hui.

Proc Natl Acad Sci U S A ; 117(18): 9857-9864, 2020 05 05.

Artículo en Inglés | MEDLINE | ID: mdl-32300017

3.

Expression of ABCA4 in the retinal pigment epithelium and its implications for Stargardt macular degeneration.

Lenis, Tamara L; Hu, Jane; Ng, Sze Yin; Jiang, Zhichun; Sarfare, Shanta; Lloyd, Marcia B; Esposito, Nicholas J; Samuel, William; Jaworski, Cynthia; Bok, Dean; Finnemann, Silvia C; Radeke, Monte J; Redmond, T Michael; Travis, Gabriel H; Radu, Roxana A.

Proc Natl Acad Sci U S A ; 115(47): E11120-E11127, 2018 11 20.

Artículo en Inglés | MEDLINE | ID: mdl-30397118

4.

Functional Rescue of Retinal Degeneration-Associated Mutant RPE65 Proteins.

Jin, Minghao; Li, Songhua; Hu, Jane; Jin, Heather H; Jacobson, Samuel G; Bok, Dean.

Adv Exp Med Biol ; 854: 525-32, 2016.

Artículo en Inglés | MEDLINE | ID: mdl-26427455

5.

Bisretinoid-mediated complement activation on retinal pigment epithelial cells is dependent on complement factor H haplotype.

Radu, Roxana A; Hu, Jane; Jiang, Zhichun; Bok, Dean.

J Biol Chem ; 289(13): 9113-20, 2014 Mar 28.

Artículo en Inglés | MEDLINE | ID: mdl-24550392

6.

Rescue of enzymatic function for disease-associated RPE65 proteins containing various missense mutations in non-active sites.

Li, Songhua; Izumi, Tadahide; Hu, Jane; Jin, Heather H; Siddiqui, Ahmed-Abdul A; Jacobson, Samuel G; Bok, Dean; Jin, Minghao.

J Biol Chem ; 289(27): 18943-56, 2014 Jul 04.

Artículo en Inglés | MEDLINE | ID: mdl-24849605

7.

Secretory defect and cytotoxicity: the potential disease mechanisms for the retinitis pigmentosa (RP)-associated interphotoreceptor retinoid-binding protein (IRBP).

Li, Songhua; Yang, Zhihui; Hu, Jane; Gordon, William C; Bazan, Nicolas G; Haas, Arthur L; Bok, Dean; Jin, Minghao.

J Biol Chem ; 288(16): 11395-406, 2013 Apr 19.

Artículo en Inglés | MEDLINE | ID: mdl-23486466

8.

The use of cultured human fetal retinal pigment epithelium in studies of the classical retinoid visual cycle and retinoid-based disease processes.

Hu, Jane; Bok, Dean.

Exp Eye Res ; 126: 46-50, 2014 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-24060345

9.

Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration.

Johnson, Lincoln V; Forest, David L; Banna, Christopher D; Radeke, Carolyn M; Maloney, Michelle A; Hu, Jane; Spencer, Christine N; Walker, Aimee M; Tsie, Marlene S; Bok, Dean; Radeke, Monte J; Anderson, Don H.

Proc Natl Acad Sci U S A ; 108(45): 18277-82, 2011 Nov 08.

Artículo en Inglés | MEDLINE | ID: mdl-21969589

10.

CAR-T cell therapy targeting surface expression of TYRP1 to treat cutaneous and rare melanoma subtypes.

Jilani, Sameeha; Saco, Justin D; Mugarza, Edurne; Pujol-Morcillo, Aleida; Chokry, Jeffrey; Ng, Clement; Abril-Rodriguez, Gabriel; Berger-Manerio, David; Pant, Ami; Hu, Jane; Gupta, Rubi; Vega-Crespo, Agustin; Baselga-Carretero, Ignacio; Chen, Jia M; Shin, Daniel Sanghoon; Scumpia, Philip; Radu, Roxana A; Chen, Yvonne; Ribas, Antoni; Puig-Saus, Cristina.

Nat Commun ; 15(1): 1244, 2024 Feb 09.

Artículo en Inglés | MEDLINE | ID: mdl-38336975

11.

Bilingual Boost.

Hu, Jane C.

Sci Am ; 318(6): 22, 2018 May 15.

Artículo en Inglés | MEDLINE | ID: mdl-29949548

12.

Complement system dysregulation and inflammation in the retinal pigment epithelium of a mouse model for Stargardt macular degeneration.

Radu, Roxana A; Hu, Jane; Yuan, Quan; Welch, Darcy L; Makshanoff, Jacob; Lloyd, Marcia; McMullen, Stephen; Travis, Gabriel H; Bok, Dean.

J Biol Chem ; 286(21): 18593-601, 2011 May 27.

Artículo en Inglés | MEDLINE | ID: mdl-21464132

13.

Molecular signature of primary retinal pigment epithelium and stem-cell-derived RPE cells.

Liao, Jo-Ling; Yu, Juehua; Huang, Kevin; Hu, Jane; Diemer, Tanja; Ma, Zhicheng; Dvash, Tamar; Yang, Xian-Jie; Travis, Gabriel H; Williams, David S; Bok, Dean; Fan, Guoping.

Hum Mol Genet ; 19(21): 4229-38, 2010 Nov 01.

Artículo en Inglés | MEDLINE | ID: mdl-20709808

14.

Baby's Rainbow.

Hu, Jane C.

Sci Am ; 317(3): 16, 2017 Aug 15.

Artículo en Inglés | MEDLINE | ID: mdl-28813395

15.

Bilingual Brains Remember.

Hu, Jane C.

Sci Am ; 316(5): 19, 2017 Apr 18.

Artículo en Inglés | MEDLINE | ID: mdl-28437406

16.

Membrane Attack Complex Mediates Retinal Pigment Epithelium Cell Death in Stargardt Macular Degeneration.

Ng, Eunice Sze Yin; Kady, Nermin; Hu, Jane; Dave, Arpita; Jiang, Zhichun; Pei, Jacqueline; Gorin, Michael B; Matynia, Anna; Radu, Roxana A.

Cells ; 11(21)2022 11 02.

Artículo en Inglés | MEDLINE | ID: mdl-36359858

17.

Assessing Variant Causality and Severity Using Retinal Pigment Epithelial Cells Derived from Stargardt Disease Patients.

Matynia, Anna; Wang, Jun; Kim, Sangbae; Li, Yumei; Dimashkie, Anupama; Jiang, Zhichun; Hu, Jane; Strom, Samuel P; Radu, Roxana A; Chen, Rui; Gorin, Michael B.

Transl Vis Sci Technol ; 11(3): 33, 2022 03 02.

Artículo en Inglés | MEDLINE | ID: mdl-35348597

18.

The role of interphotoreceptor retinoid-binding protein on the translocation of visual retinoids and function of cone photoreceptors.

Jin, Minghao; Li, Songhua; Nusinowitz, Steven; Lloyd, Marcia; Hu, Jane; Radu, Roxana A; Bok, Dean; Travis, Gabriel H.

J Neurosci ; 29(5): 1486-95, 2009 Feb 04.

Artículo en Inglés | MEDLINE | ID: mdl-19193895

19.

Geographic Atrophy: Confocal Scanning Laser Ophthalmoscopy, Histology, and Inflammation in the Region of Expanding Lesions.

Bonilha, Vera L; Bell, Brent A; Hu, Jane; Milliner, Caroline; Pauer, Gayle J; Hagstrom, Stephanie A; Radu, Roxana A; Hollyfield, Joe G.

Invest Ophthalmol Vis Sci ; 61(8): 15, 2020 07 01.

Artículo en Inglés | MEDLINE | ID: mdl-32658960

20.

Evidence of complement dysregulation in outer retina of Stargardt disease donor eyes.

Hu, Jane; Pauer, Gayle J; Hagstrom, Stephanie A; Bok, Dean; DeBenedictis, Meghan J; Bonilha, Vera L; Hollyfield, Joe G; Radu, Roxana A.

Redox Biol ; 37: 101787, 2020 10.

Artículo en Inglés | MEDLINE | ID: mdl-33214125

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Impaired cathepsin D in retinal pigment epithelium cells mediates Stargardt disease pathogenesis.

Regulatory mechanism for the transmembrane receptor that mediates bidirectional vitamin A transport.

Expression of ABCA4 in the retinal pigment epithelium and its implications for Stargardt macular degeneration.

Functional Rescue of Retinal Degeneration-Associated Mutant RPE65 Proteins.

Bisretinoid-mediated complement activation on retinal pigment epithelial cells is dependent on complement factor H haplotype.

Rescue of enzymatic function for disease-associated RPE65 proteins containing various missense mutations in non-active sites.

Secretory defect and cytotoxicity: the potential disease mechanisms for the retinitis pigmentosa (RP)-associated interphotoreceptor retinoid-binding protein (IRBP).

The use of cultured human fetal retinal pigment epithelium in studies of the classical retinoid visual cycle and retinoid-based disease processes.

Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration.

CAR-T cell therapy targeting surface expression of TYRP1 to treat cutaneous and rare melanoma subtypes.

Bilingual Boost.

Complement system dysregulation and inflammation in the retinal pigment epithelium of a mouse model for Stargardt macular degeneration.

Molecular signature of primary retinal pigment epithelium and stem-cell-derived RPE cells.

Baby's Rainbow.

Bilingual Brains Remember.

Membrane Attack Complex Mediates Retinal Pigment Epithelium Cell Death in Stargardt Macular Degeneration.

Assessing Variant Causality and Severity Using Retinal Pigment Epithelial Cells Derived from Stargardt Disease Patients.

The role of interphotoreceptor retinoid-binding protein on the translocation of visual retinoids and function of cone photoreceptors.

Geographic Atrophy: Confocal Scanning Laser Ophthalmoscopy, Histology, and Inflammation in the Region of Expanding Lesions.

Evidence of complement dysregulation in outer retina of Stargardt disease donor eyes.