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1.
Concise Enantioselective Total Synthesis of Isopavine Alkaloids.
J Org Chem
; 88(7): 4317-4324, 2023 04 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-36893742
2.
Promising tacrine/huperzine A-based dimeric acetylcholinesterase inhibitors for neurodegenerative disorders: From relieving symptoms to modifying diseases through multitarget.
J Neurochem
; 158(6): 1381-1393, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-33930191
3.
Discover Novel Covalent Inhibitors Targeting FLT3 through Hybrid Virtual Screening Strategy.
Biol Pharm Bull
; 44(12): 1872-1877, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34853270
4.
Discovery and optimization of 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one derivatives as mTORC1/mTORC2 dual inhibitors.
Bioorg Chem
; 92: 103232, 2019 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31526911
5.
Design, Synthesis and Biological Evaluation of 4-Aryl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one Derivatives as a PI3Kα Inhibitor.
Biol Pharm Bull
; 42(6): 1013-1018, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31155575
6.
Design, synthesis and biological evaluation of pyrimidine-based derivatives as VEGFR-2 tyrosine kinase inhibitors.
Bioorg Chem
; 78: 393-405, 2018 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29677483
7.
Tacrine(10)-hupyridone, a dual-binding acetylcholinesterase inhibitor, potently attenuates scopolamine-induced impairments of cognition in mice.
Metab Brain Dis
; 33(4): 1131-1139, 2018 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29564727
8.
Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3ß and the ERK Pathway.
Cell Mol Neurobiol
; 37(4): 655-664, 2017 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-27412761
9.
Design, synthesis and biological evaluation of Lenalidomide derivatives as tumor angiogenesis inhibitor.
Bioorg Med Chem Lett
; 27(17): 4075-4081, 2017 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28757066
10.
Chaihu Shugan San ameliorated cognitive deficits through regulating gut microbiota in senescence-accelerated mouse prone 8.
Front Pharmacol
; 14: 1181226, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37256236
11.
Tetramethylpyrazine nitrone exerts neuroprotection via activation of PGC-1α/Nrf2 pathway in Parkinson's disease models.
J Adv Res
; 2023 Nov 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-37989471
12.
Protection against H2O2-evoked toxicity in HT22 hippocampal neuronal cells by geissoschizine methyl ether via inhibiting ERK pathway.
Transl Neurosci
; 13(1): 369-378, 2022 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36304098
13.
Efficient synthesis of novel colchicine-magnolol hybrids and evaluation of their inhibitory activity on key proteases of 2019-nCoV replication and acute lung injury.
Nat Prod Res
; : 1-10, 2022 Oct 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-36302171
14.
Design, synthesis and biological evaluation of a novel colchicine-magnolol hybrid for inhibiting the growth of Lewis lung carcinoma in Vitro and in Vivo.
Front Chem
; 10: 1094019, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36583151
15.
Recent advance of peptide-based molecules and nonpeptidic small-molecules modulating PD-1/PD-L1 protein-protein interaction or targeting PD-L1 protein degradation.
Eur J Med Chem
; 213: 113170, 2021 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33454550
16.
If small molecules immunotherapy comes, can the prime be far behind?
Eur J Med Chem
; 218: 113356, 2021 Jun 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33773287
17.
Dimeric Tacrine(10)-hupyridone as a Multitarget-Directed Ligand To Treat Alzheimer's Disease.
ACS Chem Neurosci
; 12(13): 2462-2477, 2021 07 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-34156230
18.
Highly efficient synthesis and monoamine oxidase B inhibitory profile of demethyleneberberine, columbamine and palmatine.
Neurochem Int
; 139: 104807, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32711021
19.
Attenuation of secondary damage and Aß deposits in the ipsilateral thalamus of dMCAO rats through reduction of cathepsin B by bis(propyl)-cognitin, a multifunctional dimer.
Neuropharmacology
; 162: 107786, 2020 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31726074
20.
Multifunctional memantine nitrate significantly protects against glutamate-induced excitotoxicity via inhibiting calcium influx and attenuating PI3K/Akt/GSK3beta pathway.
Chem Biol Interact
; 325: 109020, 2020 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32092300