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1.
Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.
Cell
; 184(4): 943-956.e18, 2021 02 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-33571432
2.
Fungal Epithiodiketopiperazines Carrying α,ß-Polysulfide Bridges from Penicillium steckii YE, and Their Chemical Interconversion.
Chembiochem
; 22(2): 416-422, 2021 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32816319
3.
Secondary Metabolites from the Leather Coral-Derived Fungal Strain Xylaria sp. FM1005 and Their Glycoprotein IIb/IIIa Inhibitory Activity.
J Nat Prod
; 84(2): 466-473, 2021 02 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-33491454
4.
Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52.
Acta Pharmacol Sin
; 42(4): 633-640, 2021 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-32737469
5.
Aspochalasin H1: A New Cyclic Aspochalasin from Hawaiian Plant-Associated Endophytic Fungus Aspergillus sp. FT1307.
Molecules
; 26(14)2021 Jul 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34299514
6.
NF-κB Inhibitory and Antibacterial Helvolic and Fumagillin Derivatives from Aspergillus terreus.
J Nat Prod
; 83(3): 730-737, 2020 03 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-32163285
7.
Tryptoquivalines W and X, two new compounds from a Hawaiian fungal strain and their biological activities.
Tetrahedron Lett
; 61(14)2020 Apr 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33281236
8.
Clavukoellians A-F, Highly Rearranged Nardosinane Sesquiterpenoids with Antiangiogenic Activity from Clavularia koellikeri.
J Nat Prod
; 82(5): 1331-1337, 2019 05 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-30994348
9.
Salviachinensines A-F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal Plant Salvia chinensis.
J Nat Prod
; 81(11): 2531-2538, 2018 11 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-30370766
10.
W246(6.48) opens a gate for a continuous intrinsic water pathway during activation of the adenosineâ A2A receptor.
Angew Chem Int Ed Engl
; 54(2): 556-9, 2015 Jan 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-25403323
11.
Assessing the Performance of Traveling-salesman based Automated Path Searching (TAPS) on Complex Biomolecular Systems.
J Chem Theory Comput
; 17(8): 5301-5311, 2021 Aug 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34270241
12.
Antibacterial kaneoheoic acids A-F from a Hawaiian fungus Fusarium sp. FM701.
Phytochemistry
; 181: 112545, 2021 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-33217722
13.
Discovery of a highly potent kinase inhibitor capable of overcoming multiple imatinib-resistant ABL mutants for chronic myeloid leukemia (CML).
Eur J Pharmacol
; 897: 173944, 2021 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33581133
14.
Discovery of 6'-chloro-N-methyl-5'-(phenylsulfonamido)-[3,3'-bipyridine]-5-carboxamide (CHMFL-PI4K-127) as a novel Plasmodium falciparum PI(4)K inhibitor with potent antimalarial activity against both blood and liver stages of Plasmodium.
Eur J Med Chem
; 188: 112012, 2020 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31911293
15.
Discovery of (E)-N-(4-methyl-5-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thiazol-2-yl)-2-(4-methylpiperazin-1-yl)acetamide (IHMT-TRK-284) as a novel orally available type II TRK kinase inhibitor capable of overcoming multiple resistant mutants.
Eur J Med Chem
; 207: 112744, 2020 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32949955
16.
Discovery of (S)-2-(1-(4-Amino-3-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)propyl)-3-cyclopropyl-5-fluoroquinazolin-4(3H)-one (IHMT-PI3Kδ-372) as a Potent and Selective PI3Kδ Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease.
J Med Chem
; 63(22): 13973-13993, 2020 11 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-33180507
17.
Discovery of 2-(4-Chloro-3-(trifluoromethyl)phenyl)-N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)acetamide (CHMFL-KIT-64) as a Novel Orally Available Potent Inhibitor against Broad-Spectrum Mutants of c-KIT Kinase for Gastrointestinal Stromal Tumors.
J Med Chem
; 62(13): 6083-6101, 2019 07 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31250638
18.
Discovery of ( E)- N1-(3-Fluorophenyl)- N3-(3-(2-(pyridin-2-yl)vinyl)-1 H-indazol-6-yl)malonamide (CHMFL-KIT-033) as a Novel c-KIT T670I Mutant Selective Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs).
J Med Chem
; 62(10): 5006-5024, 2019 05 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-31046271
19.
Repurposing cabozantinib to GISTs: Overcoming multiple imatinib-resistant cKIT mutations including gatekeeper and activation loop mutants in GISTs preclinical models.
Cancer Lett
; 447: 105-114, 2019 04 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-30684595
20.
Discovery and characterization of a novel highly potent and selective type II native and drug-resistant V299L mutant BCR-ABL inhibitor (CHMFL-ABL-039) for Chronic Myeloid Leukemia (CML).
Cancer Biol Ther
; 20(6): 877-885, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-30894066