Detalles de la búsqueda
1.
Pyrazine and Phenazine Heterocycles: Platforms for Total Synthesis and Drug Discovery.
Molecules
; 27(3)2022 Feb 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35164376
2.
Progress towards a stable cephalosporin-halogenated phenazine conjugate for antibacterial prodrug applications.
Bioorg Med Chem Lett
; 30(22): 127515, 2020 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32860978
3.
Yohimbine as a Starting Point to Access Diverse Natural Product-Like Agents with Re-programmed Activities against Cancer-Relevant GPCR Targets.
Bioorg Med Chem
; 28(14): 115546, 2020 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32616180
4.
Efficacy data of halogenated phenazine and quinoline agents and an NH125 analogue to veterinary mycoplasmas.
BMC Vet Res
; 16(1): 107, 2020 Apr 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32252763
5.
Turning the Tide against Antibiotic Resistance by Evaluating Novel, Halogenated Phenazine, Quinoline, and NH125 Compounds against Ureaplasma Species Clinical Isolates and Mycoplasma Type Strains.
Antimicrob Agents Chemother
; 63(3)2019 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30642935
6.
Phenazine Antibiotic-Inspired Discovery of Bacterial Biofilm-Eradicating Agents.
Chembiochem
; 20(23): 2885-2902, 2019 12 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30811834
7.
Harnessing the Chemistry of the Indole Heterocycle to Drive Discoveries in Biology and Medicine.
Chembiochem
; 20(18): 2273-2297, 2019 09 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-30609199
8.
Transcript Profiling of MRSA Biofilms Treated with a Halogenated Phenazine Eradicating Agent: A Platform for Defining Cellular Targets and Pathways Critical to Biofilm Survival.
Angew Chem Int Ed Engl
; 57(47): 15523-15528, 2018 11 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-30230671
9.
Identification of N-Arylated NH125 Analogues as Rapid Eradicating Agents against MRSA Persister Cells and Potent Biofilm Killers of Gram-Positive Pathogens.
Chembiochem
; 18(4): 352-357, 2017 02 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-27925693
10.
A Tryptoline Ring-Distortion Strategy Leads to Complex and Diverse Biologically Active Molecules from the Indole Alkaloid Yohimbine.
Chemistry
; 23(18): 4327-4335, 2017 Mar 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-27900785
11.
Antimicrobial peptide-inspired NH125 analogues: bacterial and fungal biofilm-eradicating agents and rapid killers of MRSA persisters.
Org Biomol Chem
; 15(26): 5503-5512, 2017 Jul 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28534905
12.
Synthetically Tuning the 2-Position of Halogenated Quinolines: Optimizing Antibacterial and Biofilm Eradication Activities via Alkylation and Reductive Amination Pathways.
Chemistry
; 22(27): 9181-9, 2016 Jun 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-27245927
13.
Halogenated quinolines discovered through reductive amination with potent eradication activities against MRSA, MRSE and VRE biofilms.
Org Biomol Chem
; 13(41): 10290-4, 2015 Nov 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-26414088
14.
Halogenated Phenazines that Potently Eradicate Biofilms, MRSA Persister Cells in Non-Biofilm Cultures, and Mycobacterium tuberculosis.
Angew Chem Int Ed Engl
; 54(49): 14819-23, 2015 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26480852
15.
Discovery of quinoline small molecules with potent dispersal activity against methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis biofilms using a scaffold hopping strategy.
Bioorg Med Chem Lett
; 24(21): 5076-80, 2014 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25264073
16.
Phenazine antibiotic inspired discovery of potent bromophenazine antibacterial agents against Staphylococcus aureus and Staphylococcus epidermidis.
Org Biomol Chem
; 12(6): 881-6, 2014 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-24389824
17.
Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor.
Chembiochem
; 14(17): 2263-7, 2013 Nov 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-24174263
18.
Chemical Reactions of Indole Alkaloids That Enable Rapid Access to New Scaffolds for Discovery.
SynOpen
; 7(2): 165-185, 2023 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-37795132
19.
Design, Synthesis, and Evaluation of Carbonate-Linked Halogenated Phenazine-Quinone Prodrugs with Improved Water-Solubility and Potent Antibacterial Profiles.
ACS Infect Dis
; 9(4): 899-915, 2023 04 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-36867688
20.
Design, synthesis and evaluation of halogenated phenazine antibacterial prodrugs targeting nitroreductase enzymes for activation.
RSC Med Chem
; 14(8): 1472-1481, 2023 Aug 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-37593580