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1.
N3-substituted temozolomide analogs overcome methylguanine-DNA methyltransferase and mismatch repair precipitating apoptotic and autophagic cancer cell death.
Oncology
; 88(1): 28-48, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25277441
2.
Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014.
Bioorg Med Chem Lett
; 23(5): 1212-6, 2013 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23375793
3.
Certain imidazotetrazines escape O6-methylguanine-DNA methyltransferase and mismatch repair.
Oncology
; 80(3-4): 195-207, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-21720182
4.
The discovery and optimisation of pyrido[2,3-d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase.
Bioorg Med Chem Lett
; 19(20): 5950-3, 2009 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19762236
5.
Synthesis and growth-inhibitory activities of imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position.
Medchemcomm
; 9(3): 545-553, 2018 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30108945
6.
Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
J Med Chem
; 50(8): 1958-72, 2007 Apr 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-17371003
7.
Enantioselective formal total synthesis of the antitumor macrolide bryostatin 7.
Org Lett
; 8(20): 4477-80, 2006 Sep 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-16986929
8.
Synthesis of a simplified bryostatin C-ring analogue that binds to the CRD2 of human PKC-alpha and construction of a novel BC-analogue by an unusual Julia olefination process.
Org Lett
; 5(4): 499-502, 2003 Feb 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-12583753
9.
Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities.
J Exp Clin Cancer Res
; 33: 81, 2014 Oct 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-25288403
10.
1-substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones endowed with dual DNA-PK/PI3-K inhibitory activity.
J Med Chem
; 56(16): 6386-401, 2013 Aug 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-23855836
11.
On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts.
J Exp Clin Cancer Res
; 32: 68, 2013 Sep 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-24330541
12.
Erratum: identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities.
J Exp Clin Cancer Res
; 34: 9, 2015 Feb 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-25886908
13.
DNA-dependent protein kinase (DNA-PK) inhibitors. Synthesis and biological activity of quinolin-4-one and pyridopyrimidin-4-one surrogates for the chromen-4-one chemotype.
J Med Chem
; 53(24): 8498-507, 2010 Dec 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-21080722
14.
AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity.
Cancer Res
; 70(1): 288-98, 2010 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20028854
15.
Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion.
Mol Cancer Ther
; 8(10): 2894-902, 2009 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-19808981
16.
The chemistry and biology of the bryostatin antitumour macrolides.
Nat Prod Rep
; 19(4): 413-53, 2002 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-12195811
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