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1.
Proline isosteres in a series of 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitors of IGF-1R kinase and IR kinase.
Bioorg Med Chem Lett
; 20(17): 5027-30, 2010 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20675137
2.
Parallel synthesis of 2-aryl-4-aminobenzimidazoles and their evaluation as gonadotropin releasing hormone antagonists.
J Comb Chem
; 11(1): 117-25, 2009.
Artículo
en Inglés
| MEDLINE | ID: mdl-19049392
3.
Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor.
Cancer Res
; 65(9): 3781-7, 2005 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15867374
4.
Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity.
J Med Chem
; 48(18): 5639-43, 2005 Sep 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-16134929
5.
IRS2 copy number gain, KRAS and BRAF mutation status as predictive biomarkers for response to the IGF-1R/IR inhibitor BMS-754807 in colorectal cancer cell lines.
Mol Cancer Ther
; 14(2): 620-30, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25527633
6.
Differential mechanisms of acquired resistance to insulin-like growth factor-i receptor antibody therapy or to a small-molecule inhibitor, BMS-754807, in a human rhabdomyosarcoma model.
Cancer Res
; 70(18): 7221-31, 2010 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20807811
7.
BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR.
Mol Cancer Ther
; 8(12): 3341-9, 2009 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-19996272
8.
The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors.
Cancer Res
; 69(1): 161-70, 2009 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19117999
9.
Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development.
J Med Chem
; 52(23): 7360-3, 2009 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-19778024
10.
Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an orally efficacious inhibitor of insulin-like growth factor-1 receptor kinase with broad spectrum in vivo antitumor activity.
J Med Chem
; 51(19): 5897-900, 2008 Oct 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-18763755
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