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1.
Discovery of 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosis.
Bioorg Med Chem Lett
; 26(4): 1260-4, 2016 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26810316
2.
Genetic and pharmacological evaluation of cathepsin s in a mouse model of asthma.
Am J Respir Cell Mol Biol
; 45(1): 81-7, 2011 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-20855652
3.
3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts.
Bioorg Med Chem Lett
; 20(10): 3129-33, 2010 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20409708
4.
The behavioral and neurochemical effects of a novel D-amino acid oxidase inhibitor compound 8 [4H-thieno [3,2-b]pyrrole-5-carboxylic acid] and D-serine.
J Pharmacol Exp Ther
; 328(3): 921-30, 2009 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-19088300
5.
Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDI.
ACS Med Chem Lett
; 7(3): 312-7, 2016 Mar 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26985321
6.
Mechanism based neurotoxicity of mGlu5 positive allosteric modulators--development challenges for a promising novel antipsychotic target.
Neuropharmacology
; 82: 161-73, 2014 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-23291536
7.
The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey.
Neuropharmacology
; 64: 215-23, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-22750078
8.
T-type calcium channel antagonism produces antipsychotic-like effects and reduces stimulant-induced glutamate release in the nucleus accumbens of rats.
Neuropharmacology
; 62(3): 1413-21, 2012 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-21110986
9.
MK-801 produces a deficit in sucrose preference that is reversed by clozapine, D-serine, and the metabotropic glutamate 5 receptor positive allosteric modulator CDPPB: relevance to negative symptoms associated with schizophrenia?
Pharmacol Biochem Behav
; 95(2): 223-9, 2010 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-20122952
10.
Discovery of Oxazolobenzimidazoles as Positive Allosteric Modulators for the mGluR2 Receptor.
ACS Med Chem Lett
; 1(8): 406-10, 2010 Nov 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900224
11.
Combined administration of an mGlu2/3 receptor agonist and a 5-HT 2A receptor antagonist markedly attenuate the psychomotor-activating and neurochemical effects of psychostimulants.
Psychopharmacology (Berl)
; 206(4): 641-51, 2009 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-19707745
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