Detalles de la búsqueda
1.
Cereblon contributes to cardiac dysfunction by degrading Cav1.2α.
Eur Heart J
; 43(20): 1973-1989, 2022 05 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-35190817
2.
Structure-activity relationship analysis of novel GSPT1 degraders based on benzotriazinone scaffold and its antitumor effect on xenograft mouse model.
Bioorg Chem
; 127: 105923, 2022 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35717803
3.
Induced protein degradation of anaplastic lymphoma kinase (ALK) by proteolysis targeting chimera (PROTAC).
Biochem Biophys Res Commun
; 505(2): 542-547, 2018 10 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-30274779
4.
Grignard-mediated rearrangement of trifluoroacetyl from dihydroisoquinoline enamides to afford tertiary trifluoromethylcarbinols.
Org Biomol Chem
; 16(9): 1452-1456, 2018 02 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-29431808
5.
Synthesis and biological evaluation of N9-cis-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitors.
Bioorg Med Chem Lett
; 27(18): 4399-4404, 2017 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28827110
6.
Novel 2,4-diaminopyrimidines bearing fused tricyclic ring moiety for anaplastic lymphoma kinase (ALK) inhibitor.
Bioorg Med Chem Lett
; 27(10): 2185-2191, 2017 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28385505
7.
Synthesis and Molecular Modeling Studies of N'-Hydroxyindazolecarboximidamides as Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors.
Molecules
; 22(11)2017 Nov 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-29120388
8.
Novel 2,4-diaminopyrimidines bearing tetrahydronaphthalenyl moiety against anaplastic lymphoma kinase (ALK): Synthesis, in vitro, ex vivo, and in vivo efficacy studies.
Bioorg Med Chem Lett
; 26(7): 1720-5, 2016 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26923695
9.
Discovery of novel tetrahydroisoquinoline-containing pyrimidines as ALK inhibitors.
Bioorg Med Chem
; 24(2): 207-19, 2016 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26712094
10.
Development of potent ALK inhibitor and its molecular inhibitory mechanism against NSCLC harboring EML4-ALK proteins.
Biochem Biophys Res Commun
; 464(3): 762-7, 2015 Aug 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-26168728
11.
Synthesis and evaluation of novel 2,4-diaminopyrimidines bearing bicyclic aminobenzazepines for anaplastic lymphoma kinase (ALK) inhibitor.
Bioorg Med Chem Lett
; 25(18): 3992-8, 2015 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26235945
12.
Discovery of substituted 6-pheny-3H-pyridazin-3-one derivatives as novel c-Met kinase inhibitors.
Bioorg Med Chem Lett
; 24(21): 5093-7, 2014 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25282552
13.
Serendipitous discovery of 2-((phenylsulfonyl)methyl)-thieno[3,2-d]pyrimidine derivatives as novel HIV-1 replication inhibitors.
Bioorg Med Chem Lett
; 24(23): 5473-7, 2014 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25455487
14.
Antitrypanosomal Chloronitrobenzamides.
J Med Chem
; 67(5): 3437-3447, 2024 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-38363074
15.
Synthesis and evaluation of methylsulfonylnitrobenzamides (MSNBAs) as inhibitors of the thyroid hormone receptor-coactivator interaction.
Bioorg Med Chem Lett
; 23(6): 1891-5, 2013 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23414840
16.
Optimization of the electrophile of chloronitrobenzamide leads active against Trypanosoma brucei.
Bioorg Med Chem Lett
; 23(14): 4127-31, 2013 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23746473
17.
Identification of a series of 1,3,4-trisubstituted pyrazoles as novel hepatitis C virus entry inhibitors.
Bioorg Med Chem Lett
; 23(23): 6467-73, 2013 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24125883
18.
Synthesis and biological evaluation of triazolothienopyrimidine derivatives as novel HIV-1 replication inhibitors.
Bioorg Med Chem Lett
; 23(1): 153-7, 2013 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23206860
19.
Methylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone.
J Biol Chem
; 286(14): 11895-908, 2011 Apr 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-21321127
20.
Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitor.
Bioorg Med Chem Lett
; 22(24): 7297-301, 2012 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23159569