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1.
Targeted quantitative proteomics for the analysis of 14 UGT1As and -2Bs in human liver using NanoUPLC-MS/MS with selected reaction monitoring.
J Proteome Res
; 12(10): 4402-13, 2013 Oct 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-23977844
2.
Progress curve mechanistic modeling approach for assessing time-dependent inhibition of CYP3A4.
Drug Metab Dispos
; 40(9): 1658-67, 2012 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-22621802
3.
Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors.
Drug Metab Dispos
; 40(5): 1051-65, 2012 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-22357286
4.
Selective mechanism-based inactivation of CYP3A4 by CYP3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of CYP3A4 versus CYP3A5 in the metabolism of drugs.
Drug Metab Dispos
; 40(9): 1686-97, 2012 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-22645092
5.
Medicinal chemistry approaches to avoid aldehyde oxidase metabolism.
Bioorg Med Chem Lett
; 22(8): 2856-60, 2012 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22429467
6.
Investigation into UDP-glucuronosyltransferase (UGT) enzyme kinetics of imidazole- and triazole-containing antifungal drugs in human liver microsomes and recombinant UGT enzymes.
Drug Metab Dispos
; 38(6): 923-9, 2010 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-20304965
7.
Excretion and metabolism of lersivirine (5-{[3,5-diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a next-generation non-nucleoside reverse transcriptase inhibitor, after administration of [14C]Lersivirine to healthy volunteers.
Drug Metab Dispos
; 38(5): 789-800, 2010 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-20124396
8.
Comparison of different algorithms for predicting clinical drug-drug interactions, based on the use of CYP3A4 in vitro data: predictions of compounds as precipitants of interaction.
Drug Metab Dispos
; 37(8): 1658-66, 2009 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-19406954
9.
In vitro and in vivo glucuronidation of midazolam in humans.
Br J Clin Pharmacol
; 67(4): 445-54, 2009 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-19371318
10.
Maraviroc: in vitro assessment of drug-drug interaction potential.
Br J Clin Pharmacol
; 66(4): 498-507, 2008 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-18647303
11.
Application of CYP3A4 in vitro data to predict clinical drug-drug interactions; predictions of compounds as objects of interaction.
Br J Clin Pharmacol
; 65(5): 680-92, 2008 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-18279465
12.
Utility of human/human-derived reagents in drug discovery and development: An industrial perspective.
Environ Toxicol Pharmacol
; 21(2): 179-83, 2006 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-21783655
13.
Reaction phenotyping in drug discovery: moving forward with confidence?
Curr Drug Metab
; 4(6): 527-34, 2003 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-14683480
14.
Understanding CYP2D6 interactions.
Drug Discov Today
; 14(19-20): 964-72, 2009 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-19638317
15.
Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds.
J Pharmacol Toxicol Methods
; 58(3): 206-14, 2008.
Artículo
en Inglés
| MEDLINE | ID: mdl-18634893
16.
Induction of cytochrome P450: assessment in an immortalized human hepatocyte cell line (Fa2N4) using a novel higher throughput cocktail assay.
Drug Metab Dispos
; 35(2): 275-82, 2007 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-17108058
17.
Minimizing polymorphic metabolism in drug discovery: evaluation of the utility of in vitro methods for predicting pharmacokinetic consequences associated with CYP2D6 metabolism.
Drug Metab Dispos
; 34(9): 1516-22, 2006 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-16763018
18.
Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios.
Drug Metab Dispos
; 32(11): 1201-8, 2004 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-15304429
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