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1.
Development of certain benzylidene coumarin derivatives as anti-prostate cancer agents targeting EGFR and PI3Kß kinases.
J Enzyme Inhib Med Chem
; 39(1): 2311157, 2024 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-38348846
2.
Schiff bases as linker in the development of quinoline-sulfonamide hybrids as selective cancer-associated carbonic anhydrase isoforms IX/XII inhibitors: A new regioisomerism tactic.
Bioorg Chem
; 131: 106309, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36502567
3.
Design and synthesis of uracil/thiouracil based quinoline scaffolds as topoisomerases I/II inhibitors for chemotherapy: A new hybrid navigator with DFT calculation.
Bioorg Chem
; 136: 106560, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37121108
4.
Drug repositioning: doxazosin attenuates the virulence factors and biofilm formation in Gram-negative bacteria.
Appl Microbiol Biotechnol
; 107(11): 3763-3778, 2023 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-37079062
5.
Design, synthesis and antitumor evaluation of novel pyrazolo[3,4-d]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors.
J Enzyme Inhib Med Chem
; 38(1): 203-215, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36382444
6.
Human dihydrofolate reductase inhibition effect of 1-Phenylpyrazolo[3,4-d]pyrimidines: Synthesis, antitumor evaluation and molecular modeling study.
Bioorg Chem
; 129: 106207, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36270170
7.
Design and synthesis of ibuprofen-quinoline conjugates as potential anti-inflammatory and analgesic drug candidates.
Bioorg Chem
; 119: 105557, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34952242
8.
Novel Sunifiram-carbamate hybrids as potential dual acetylcholinesterase inhibitor and NMDAR co-agonist: simulation-guided analogue design and pharmacological screening.
J Enzyme Inhib Med Chem
; 37(1): 1241-1256, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-35484855
9.
Synthesis, Antimicrobial, Anti-Virulence and Anticancer Evaluation of New 5(4H)-Oxazolone-Based Sulfonamides.
Molecules
; 27(3)2022 Jan 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-35163939
10.
Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach.
Molecules
; 27(18)2022 Sep 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36144662
11.
Novel 1,2,4-oxadiazole-chalcone/oxime hybrids as potential antibacterial DNA gyrase inhibitors: Design, synthesis, ADMET prediction and molecular docking study.
Bioorg Chem
; 111: 104885, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33838559
12.
Design, synthesis and pharmacological screening of novel renoprotective methionine-based peptidomimetics: Amelioration of cisplatin-induced nephrotoxicity.
Bioorg Chem
; 114: 105100, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34246972
13.
New quinoline-triazole conjugates: Synthesis, and antiviral properties against SARS-CoV-2.
Bioorg Chem
; 114: 105117, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34214752
14.
Novel chalcone/aryl carboximidamide hybrids as potent anti-inflammatory via inhibition of prostaglandin E2 and inducible NO synthase activities: design, synthesis, molecular docking studies and ADMET prediction.
J Enzyme Inhib Med Chem
; 36(1): 1067-1078, 2021 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-34027787
15.
Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect.
J Enzyme Inhib Med Chem
; 36(1): 802-818, 2021 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-33730937
16.
Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on bumetanide scaffold.
Bioorg Chem
; 100: 103878, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32361486
17.
Design and synthesis of novel pyrazolo[3,4-d]pyrimidin-4-one bearing quinoline scaffold as potent dual PDE5 inhibitors and apoptotic inducers for cancer therapy.
Bioorg Chem
; 105: 104352, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33080494
18.
Design, synthesis and anticancer activity of novel valproic acid conjugates with improved histone deacetylase (HDAC) inhibitory activity.
Bioorg Chem
; 99: 103797, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32247939
19.
Design, synthesis and biological evaluation of novel 5-((substituted quinolin-3-yl/1-naphthyl) methylene)-3-substituted imidazolidin-2,4-dione as HIV-1 fusion inhibitors.
Bioorg Chem
; 99: 103782, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32229348
20.
An Efficient Greener Approach for N-Acylation of Amines in Water Using Benzotriazole Chemistry.
Molecules
; 25(11)2020 May 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-32481504