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1.
Physiologically based pharmacokinetic modelling to predict the clinical effect of CYP3A inhibitors/inducers on esaxerenone pharmacokinetics in healthy subjects and subjects with hepatic impairment.
Eur J Clin Pharmacol
; 78(1): 65-73, 2022 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-34415382
2.
Identification and Characterization of a New Carboxylesterase 2 Isozyme, mfCES2C, in the Small Intestine of Cynomolgus Monkeys.
Drug Metab Dispos
; 48(3): 146-152, 2020 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31836607
3.
Fibroblast growth factor receptor modulators employing diamines with reduced phospholipidosis-inducing potential.
Bioorg Med Chem
; 28(14): 115562, 2020 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32616184
4.
Discovery of 1,2,3-triazole-based fibroblast growth factor receptor modulators.
Bioorg Med Chem Lett
; 29(16): 2332-2337, 2019 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31255484
5.
Analysis of carboxylesterase 2 transcript variants in cynomolgus macaque liver.
Xenobiotica
; 49(2): 247-255, 2019 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-29384423
6.
Correction to: Physiologically based pharmacokinetic modelling to predict the clinical effect of CYP3A inhibitors/inducers on esaxerenone pharmacokinetics in healthy subjects and subjects with hepatic impairment.
Eur J Clin Pharmacol
; 78(1): 75, 2022 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-34494163
7.
Differences in Intestinal Hydrolytic Activities between Cynomolgus Monkeys and Humans: Evaluation of Substrate Specificities Using Recombinant Carboxylesterase 2 Isozymes.
Mol Pharm
; 13(9): 3176-86, 2016 09 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-27454346
8.
Orally active ghrelin receptor inverse agonists and their actions on a rat obesity model.
Bioorg Med Chem
; 23(15): 4792-4803, 2015 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26100441
9.
In vitro and in vivo metabolism of a novel chymase inhibitor, SUN13834, and the predictability of human metabolism using mice with humanized liver.
Xenobiotica
; 44(2): 154-63, 2014 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-24304169
10.
Pharmacokinetics of Edoxaban 15 mg in Very Elderly Patients with Nonvalvular Atrial Fibrillation: A Subanalysis of the ELDERCARE-AF Study.
Thromb Haemost
; 2024 Apr 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-38641335
11.
Bioequivalence of Esaxerenone Conventional Tablet and Orally Disintegrating Tablet: Two Single-Dose Crossover Studies in Healthy Japanese Men.
Clin Pharmacol Drug Dev
; 11(8): 957-965, 2022 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35315257
12.
Effects of Repeated Oral Administration of Esaxerenone on the Pharmacokinetics of Midazolam in Healthy Japanese Males.
Eur J Drug Metab Pharmacokinet
; 46(5): 685-694, 2021 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-34383278
13.
[Pharmacological profile, clinical efficacy, and safety of esaxerenone (Minnebro® tablets 1.25â mg, 2.5â mg, 5â mg)].
Nihon Yakurigaku Zasshi
; 155(5): 340-350, 2020.
Artículo
en Japonés
| MEDLINE | ID: mdl-32879177
14.
Evaluation of ovotoxicity induced by 7, 12-dimethylbenz[a]anthracene and its 3,4-diol metabolite utilizing a rat in vitro ovarian culture system.
Toxicol Appl Pharmacol
; 234(3): 361-9, 2009 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19027032
15.
SUN11602-induced hyperexpression of calbindin D-28k is pivotal for the survival of hippocampal neurons under neurotoxic conditions.
Brain Res
; 1594: 71-81, 2015 Jan 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-25449889
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