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1.
Exploring the dual effect of novel 1,4-diarylpyranopyrazoles as antiviral and anti-inflammatory for the management of SARS-CoV-2 and associated inflammatory symptoms.
Bioorg Chem
; 130: 106255, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36403336
2.
Design and Synthesis of Benzene Homologues Tethered with 1,2,4-Triazole and 1,3,4-Thiadiazole Motifs Revealing Dual MCF-7/HepG2 Cytotoxic Activity with Prominent Selectivity via Histone Demethylase LSD1 Inhibitory Effect.
Int J Mol Sci
; 23(15)2022 Aug 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35955929
3.
Design of molecular hybrids of phthalimide-triazole agents with potent selective MCF-7/HepG2 cytotoxicity: Synthesis, EGFR inhibitory effect, and metabolic stability.
Bioorg Chem
; 111: 104835, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33798850
4.
Design, synthesis, molecular docking of new lipophilic acetamide derivatives affording potential anticancer and antimicrobial agents.
Bioorg Chem
; 76: 332-342, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29227917
5.
Synthesis, Modelling, and Anticonvulsant Studies of New Quinazolines Showing Three Highly Active Compounds with Low Toxicity and High Affinity to the GABA-A Receptor.
Molecules
; 22(2)2017 Jan 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-28125041
6.
Self Organizing Map-Based Classification of Cathepsin k and S Inhibitors with Different Selectivity Profiles Using Different Structural Molecular Fingerprints: Design and Application for Discovery of Novel Hits.
Molecules
; 21(2): 175, 2016 Jan 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-26840291
7.
Radiosensitizing activity of a novel Benzoxazine through the promotion of apoptosis and inhibition of DNA repair.
Invest New Drugs
; 32(3): 424-35, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24627282
8.
The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, in vitro, and in silico mechanistic investigations.
J Biomol Struct Dyn
; 41(21): 12411-12425, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-36661285
9.
In vitro and computational investigations of novel synthetic carboxamide-linked pyridopyrrolopyrimidines with potent activity as SARS-CoV-2-MPro inhibitors.
RSC Adv
; 12(41): 26895-26907, 2022 Sep 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-36320844
10.
Synthesis, DNA-PK inhibition, anti-platelet activity studies of 2-(N-substituted-3-aminopyridine)-substituted-1,3-benzoxazines and DNA-PK and PI3K inhibition, homology modelling studies of 2-morpholino-(7,8-di and 8-substituted)-1,3-benzoxazines.
Eur J Med Chem
; 57: 85-101, 2012 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-23059543
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