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1.
RNA polymerase II condensate formation and association with Cajal and histone locus bodies in living human cells.
Genes Cells
; 26(5): 298-312, 2021 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-33608942
2.
Discovery of orally efficacious RORγt inverse agonists. Part 2: Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives.
Bioorg Med Chem
; 26(2): 470-482, 2018 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29258712
3.
Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part II: Optimization of 4-(pyrrolidin-1-yl)benzonitrile derivatives.
Bioorg Med Chem Lett
; 27(9): 1897-1901, 2017 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28363748
4.
Cleavage of Target DNA Promotes Sequence Conversion with a Tailed Duplex.
Biol Pharm Bull
; 39(8): 1392-5, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27476948
5.
Synthetic studies of centromere-associated protein-E (CENP-E) inhibitors: 1.Exploration of fused bicyclic core scaffolds using electrostatic potential map.
Bioorg Med Chem
; 21(17): 5488-502, 2013 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23816042
6.
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives.
Bioorg Med Chem
; 20(18): 5600-15, 2012 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22883026
7.
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 2. Synthesis and characterization of a novel imide-type prodrug for improving oral absorption.
Bioorg Med Chem
; 20(15): 4680-92, 2012 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22763369
8.
Discovery of a Novel, Highly Potent, and Selective Thieno[3,2-d]pyrimidinone-Based Cdc7 Inhibitor with a Quinuclidine Moiety (TAK-931) as an Orally Active Investigational Antitumor Agent.
J Med Chem
; 63(3): 1084-1104, 2020 02 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-31895562
9.
Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor γt (RORγt) Agonist Structure-Based Functionality Switching Approach from In House RORγt Inverse Agonist to RORγt Agonist.
J Med Chem
; 62(3): 1167-1179, 2019 02 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30652849
10.
Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor.
Sci Adv
; 5(5): eaav3660, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-31131319
11.
A Highly Bioactive Lys-Deficient IFN Leads to a Site-Specific Di-PEGylated IFN with Equivalent Bioactivity to That of Unmodified IFN-α2b.
ACS Synth Biol
; 7(11): 2537-2546, 2018 11 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-30277749
12.
Discovery of [ cis-3-({(5 R)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1 H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5 H)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist.
J Med Chem
; 61(7): 2973-2988, 2018 04 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29510038
13.
Comparison of DNA fragments as donor DNAs upon sequence conversion of cleaved target DNA.
Nucleosides Nucleotides Nucleic Acids
; 36(6): 428-434, 2017 Jun 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-28486036
14.
Design, synthesis, and structure-activity relationships of thieno[2,3-b]pyridin-4-one derivatives as a novel class of potent, orally active, non-peptide luteinizing hormone-releasing hormone receptor antagonists.
J Med Chem
; 49(13): 3809-25, 2006 Jun 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-16789738
15.
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors. 1. Exploration of [5,6]-fused bicyclic scaffolds.
J Med Chem
; 55(7): 3452-78, 2012 Apr 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-22376051
16.
Discovery of 1-{4-[1-(2,6-difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a potent, orally active, non-peptide antagonist of the human gonadotropin-releasing hormone receptor.
J Med Chem
; 54(14): 4998-5012, 2011 Jul 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-21657270
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